Clinical treatment response achievable with conventional chemotherapy in high-grade
osteosarcoma (OS) is severely limited by the presence of intrinsic or acquired drug …

An alternative strategy, which has been suggested to overcome the ABCB1-mediated drug
resistance, may be based on the use of curcumin, a phenolic compound used in the …

The ATP-binding cassette (ABC) transporter superfamily consists of several proteins with a
wide repertoire of functions. Under physiological conditions, ABC transporters are involved …

The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in
osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation …

P-glycoprotein (P-gp), encoded by the ABCB1 (ATP-binding cassette transporter superfamily
B member 1) gene, is a transport protein involved in the efflux and distribution of the …

Background Standard treatment for osteosarcoma patients consists of a combination of
cisplatin, adriamycin, and methotrexate before surgical resection of the primary tumour …

Simple Summary Globally, colorectal cancer (CRC) is a leading cause of cancer deaths and
chemotherapy, in combination with radiotherapy when appropriate, is used to treat the …

Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-
transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be …

Background Overexpression of ATP‐binding cassette (ABC) transporter is a major
contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide …

The overexpression of ATP-binding cassette (ABC) transporters is closely associated with
the development of multidrug resistance (MDR) in certain types of cancer, which represents …