Solid tumors and hematological cancers contain small population of tumor cells that are
believed to play a critical role in the development and progression of the disease. These …

The traditional view of cancer asserts that a malignant tumour is composed of a population
of cells, all of which share the ability to divide without limit. Within the last decade, however …

Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

Simple Summary Cancer stem cell (CSC) directed therapies have been increasingly
developed during the last years. However, some reported experiments using this strategy …

Simple Summary Phenotypical heterogeneity constitutes a feature of tumors that strongly
impacts their growth and stability as well as possible therapies. Among the biological …

The recently developed concept of cancer stem cells (CSC) sheds new light on various
aspects of tumor growth and progression. Here, we present a mathematical model of …

Background The Cancer Stem Cell (CSC) hypothesis has gained credibility within the
cancer research community. According to this hypothesis, a small subpopulation of cells …

Evidence has accumulated that characterizes highly tumorigenic cancer cells residing in
heterogeneous populations. The accepted term for such a subpopulation is cancer stem …

Human cancers are thought to be sustained in their growth by a pathologic counterpart of
normal adult stem cells: cancer stem cells. This concept was first developed in human …

Similar to normal tissues, tumor tissues are frequently composed of a heterogeneous
population of cancer cells, containing multiple cellular subtypes. One explanation for the …