Extensive infiltration by tumor-associated macrophages (TAM) in combination with myeloid-
derived suppressor cells constitute the immunosuppressive microenvironment and promote …

Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the
underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal …

Background We previously demonstrated that the local immune status correlated with the
glioma prognosis. Interleukin-6 (IL6) was identified as an important local immune-related …

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion,
and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote …

Glioma stem-like cells (GSC) promote tumor generation and progression. However, the
mechanism of GSC induction or maintenance is largely unknown. We previously …

Background Deregulation of the nuclear factor of activated T cell (NFAT) pathway has been
reported in several human cancers. Particularly, NFAT2 is involved in the malignant …

Abstract Calcium/Calcineurin/Nuclear Factor of Activated T cells (Ca/CN/NFAT) signalling
pathway is the main calcium (Ca2+) dependent signalling pathway involved in the …

Tumor-associated macrophages (TAM) play a crucial role in immunosuppression. However,
how TAMs are transformed into immunosuppressive phenotypes and influence the tumor …

Nuclear factor of activated T cells 1 (NFATc1) is mainly expressed in tumor
microenvironment, especially in macrophages. However, whether NFATc1 is involved in the …

Abstract Aims Tumor‐associated macrophages (TAMs) in the immune microenvironment
play an important role in the increased drug resistance and recurrence of malignant glioma …