Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Atherosclerosis can be regarded as a chronic disease derived from the interaction between
disordered lipoproteins and an unsuitable immune response. The evolution of foam cells is …

Atherosclerosis is a chronic disease characterized by the deposition of excessive
cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence …

Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

Atherosclerosis is associated with acute cardiovascular conditions, such as ischemic heart
disease, myocardial infarction, and stroke, and is the leading cause of morbidity and …

The limited efficacy of current treatment strategies for targeting atherosclerosis and its
complications requires new therapeutic options to be explored. From early fatty-streak …

Foam cell formation due to excessive accumulation of cholesterol by macrophages is a
pathological hallmark of atherosclerosis. Macrophages cannot limit the uptake of cholesterol …

Cholesterol ester-laden macrophage foam cells are a hallmark of atherosclerosis. The cycle
of esterification and hydrolysis of cholesterol esters is one of the key steps in macrophage …

Foam cell formation from macrophages with subsequent fatty streak formation plays a key
role in early atherogenesis. Foam cell formation is thought to be induced by Low Density …

Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …