Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulence

K Ueno, A Nagamori, NO Honkyu, M Kataoka… - Medical …, 2023 - academic.oup.com
Cryptococcus neoformans is the primary causative agent of cryptococcosis. Since C.
neoformans thrives in environments and its optimal growth temperature is 25–30° C, it …

Unraveling the mechanism of thermotolerance by Set302 in Cryptococcus neoformans

Y Ni, Y Qiao, X Tian, H Li, Y Meng, C Li… - Microbiology …, 2024 - Am Soc Microbiol
The underlying mechanism of thermotolerance, which is a key virulence factor essential for
pathogenic fungi such as Cryptococcus neoformans, is largely unexplored. In this study, our …

Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

C Fu, SR Beattie, AJ Jezewski, N Robbins… - Genetics, 2022 - academic.oup.com
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

Genetic contribution to high temperature tolerance in Cryptococcus neoformans

PR Stempinski, JM Zielinski, NH Dbouk, ES Huey… - Genetics, 2021 - academic.oup.com
The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …

Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis

B Zhai - 2014 - oaktrust.library.tamu.edu
Cryptococcosis is one of the leading causes of the deaths among AIDS patients. The high
mortality rates of cryptococcosis are mainly due to inadequate information of its major …

Cryptococcus neoformans Pathogenicity

RT Nelson, JK Lodge - Fungal Genomics, 2006 - Springer
Abbreviations: BAC, bacterial artificial chromosome; CHEF, contour-clamped homogeneous
electric field; CSF, cerebral spinal fluid; EST, expressed sequence tag; GalXM …

[HTML][HTML] Identification of novel temperature-regulated genes in the human pathogen Cryptococcus neoformans using representational difference analysis

LKR e Silva, CC Staats, LS Goulart, LG Morello… - Research in …, 2008 - Elsevier
Cryptococcus neoformans is a basidiomycetous fungus and an opportunistic human
pathogen that causes infections in both immunocompromised and immunocompetent hosts …

Beyond the big three: systematic analysis of virulence factors in Cryptococcus neoformans

J Kronstad, WH Jung, G Hu - Cell Host & Microbe, 2008 - cell.com
The fungal pathogen Cryptococcus neoformans has three major virulence factors: growth at
37° C, capsule synthesis, and melanin formation. Recently in Cell, Liu et al.(2008) employed …

Regulation of virulence factors, carbon utilization and virulence by SNF1 in Cryptococcus neoformans JEC21 and divergent actions of SNF1 between cryptococcal …

J Yang, D Li, X Liu, J Pan, B Yan, X Zhu - Fungal Genetics and Biology, 2010 - Elsevier
We describe here the functions of a Snf1/AMPK homolog in the human pathogenic yeast
Cryptococcusneoformans, strain JEC21. We found that JEC21 SNF1 is a key regulator for …

[PDF][PDF] S5.3a Unraveling the genetic determinants of virulence in Cryptococcus neoformans

K Jackson, D Kisakye, M Macchietto, P Tiffen… - Medical …, 2022 - academic.oup.com
S5. 3 Cellular pleomorphism and fungal virulence, September 22, 2022, 3: 00 PM-4: 30 PM
Cryptococcus neoformans is a human pathogenic basidiomycete yeast that can cause …