Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine
glioma), are pediatric tumors of the central nervous system (CNS). Recognized as the most …

Diffuse midline glioma (DMG) is an incurable malignancy with the highest mortality rate
among pediatric brain tumors. While radiotherapy and chemotherapy are the most common …

Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of
pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall …

Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …

Purpose Our understanding of diffuse midline glioma (DMG) biology inclusive of diffuse
intrinsic pontine glioma has been revolutionized by the discovery of novel mutations on the …

The preclinical and clinical development of novel immunotherapies for the treatment of
central nervous system (CNS) tumors is advancing at a rapid pace. High-grade gliomas …

Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal CNS tumor
diagnosed in 300 American children per year. Radiation is the only effective treatment and …

Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children.
DMG typically presents with variable neurologic symptoms between ages 3 and 10 …

Diffuse midline gliomas (DMGs) are rare and devastating tumors with limited therapeutic
options. Programmed death‐ligand 1 (PD‐L1) expression represents a potential predictive …