Functional Analysis of the Acinetobacter baumannii XerC and XerD Site-Specific Recombinases: Potential Role in Dissemination of Resistance Genes

DL Lin, GM Traglia, R Baker, DJ Sherratt, MS Ramirez… - Antibiotics, 2020 - mdpi.com
Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the
vast majority of which were found in Acinetobacter baumannii, are thought to behave as …

Mobilization of pdif modules in Acinetobacter: A novel mechanism for antibiotic resistance gene shuffling?

P Balalovski, I Grainge - Molecular microbiology, 2020 - Wiley Online Library
XerCD‐dif site‐specific recombination is a well characterized system, found in most bacteria
and archaea. Its role is resolution of chromosomal dimers that arise from homologous …

Site-specific recombination at XerC/D sites mediates the formation and resolution of plasmid co-integrates carrying a bla OXA-58-and Tn aphA6-resistance module in …

MM Cameranesi, J Morán-Barrio… - Frontiers in …, 2018 - frontiersin.org
Members of the genus Acinetobacter possess distinct plasmid types which provide effective
platforms for the acquisition, evolution, and dissemination of antimicrobial resistance …

Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination in Acinetobacter baumannii Rep_3 superfamily resistance …

L Giacone, MM Cameranesi, RI Sanchez… - Frontiers in …, 2023 - frontiersin.org
The acquisition of bla OXA genes encoding different carbapenem-hydrolyzing class-D β-
lactamases (CHDL) represents a main determinant of carbapenem resistance in the …

DNA sequence of recombinase‐binding sites can determine Xer site‐specific recombination outcome

JAR Blake, N Ganguly, DJ Sherratt - Molecular microbiology, 1997 - Wiley Online Library
Xer site‐specific recombination functions in the stable inheritance of circular plasmids and
bacterial chromosomes. Two related recombinases, XerC and XerD, mediate this …

Relating primary structure to function in the Escherichia coli XerD site‐specific recombinase

AJ Spiers, DJ Sherratt - Molecular microbiology, 1997 - Wiley Online Library
XerC and XerD are related 298‐amino‐acid site‐specific recombinases, each of which is
responsible for the exchange of one pair of strands in Xer recombination. Both …

C‐terminal interactions between the XerC and XerD site‐specific recombinases

AJ Spiers, DJ Sherratt - Molecular microbiology, 1999 - Wiley Online Library
Studies of the site‐specific recombinase Cre suggest a key role for interactions between the
C‐terminus of the protein and a region located about 30 residues from the C‐terminus in …

Differences in Resolution of mwr-Containing Plasmid Dimers Mediated by the Klebsiella pneumoniae and Escherichia coli XerC Recombinases: Potential …

D Bui, J Ramiscal, S Trigueros, JS Newmark… - Journal of …, 2006 - Am Soc Microbiol
Xer-mediated dimer resolution at the mwr site of the multiresistance plasmid pJHCMW1 is
osmoregulated in Escherichia coli containing either the Escherichia coli Xer recombination …

Evolution of Acinetobacter baumannii plasmids carrying the oxa58 carbapenemase resistance gene via plasmid fusion, IS26-mediated events and dif module shuffling

NI Jones, CJ Harmer, M Hamidian, RM Hall - Plasmid, 2022 - Elsevier
Abstract Acinetobacter baumannii RepAci1-RepAci10 plasmids pA388 from a global clone 1
(GC1) isolate from Greece, and pACICU1 and variant pACICU1b from an Italian GC2 isolate …

Cloning and characterisation of the Proteus mirabilis xerD gene

M Villion, G Szatmari - FEMS microbiology letters, 1998 - academic.oup.com
The Xer site-specific recombination system is involved in the stable maintenance of
replicons (certain plasmids and chromosomes) in Escherichia coli and other bacteria by …