Pharmacologic treatment for the symptoms of painful neuropathy has been problematic,
because there has been limited understanding of the underlying etiologies and systemic …

Sensory polyneuropathy is a disabling condition for which there are no currently available
effective therapies. Chronic pain is a condition that, despite the availability of many treatment …

Objectives. Chronic neuropathic pain has been an enigma to physicians and researchers for
decades. A better understanding of its pathophysiology has given us more insight into its …

Neuropathic pain is notoriously difficult to treat; currently available pharmaceutical drugs
result in moderate analgesia in approximately a third of patients. As our understanding of the …

Chronic pain represents a clinical problem of enormous impact. Understanding of the
anatomy, pharmacology, and physiology of pain has resulted in the identification of new …

Pharmacological approaches to our understanding and treatment of pain have had a long
history and have traditionally relied on very few drugs that either have significant side effects …

Chronic pain is a highly prevalent condition that impacts adversely on individual quality of
life, imposes substantial costs on the healthcare system and a considerable burden on …

Chronic pain is a major health concern affecting 80million Americans at some time in their
lives with significant associated morbidity and effects on individual quality of life. Chronic …

Chronic pain is a major health concern that affects millions of people. There are no
adequate long‐term therapies for chronic pain sufferers, leading to significant cost for both …

EDITORIAL Fink & Wolfe peptides, the endogenous agonists for the δ-opioid receptor. The
human clinical trial was preceded by preclinical studies that examined the effect of HSV …