Impact of Endurance Training on Regeneration of Axons, Glial Cells, and Inhibitory Neurons after Spinal Cord Injury: A Link between Functional Outcome and …

K Kiss Bimbova, M Bacova, A Kisucka, J Gálik… - International Journal of …, 2023 - mdpi.com
Endurance training prior to spinal cord injury (SCI) has a beneficial effect on the activation of
signaling pathways responsible for survival, neuroplasticity, and neuroregeneration. It is …

Activation of three major signaling pathways after endurance training and spinal cord injury

K Kiss Bimbova, M Bacova, A Kisucka, J Galik… - Molecular …, 2022 - Springer
We aimed to investigate the effects of endurance training on expression of growth factors
(GFs) and stimulation of neurotrophin-dependent signaling pathways (PI3k/Akt, PLCγ/PKC …

The effects and potential mechanisms of locomotor training on improvements of functional recovery after spinal cord injury

P Yu, W Zhang, Y Liu, C Sheng, KF So, L Zhou… - International review of …, 2019 - Elsevier
Body-weight-supported locomotor training is an activity-based therapy used frequently to
train individuals with spinal cord injury (SCI) for restoring walking ability. Locomotor training …

The Impact of Treadmill Training on Tissue Integrity, Axon Growth, and Astrocyte Modulation

T Ageeva, D Sabirov, A Sufianov, E Davletshin… - International Journal of …, 2024 - mdpi.com
Spinal cord injury (SCI) presents a complex challenge in neurorehabilitation, demanding
innovative therapeutic strategies to facilitate functional recovery. This study investigates the …

Exercise-induced plasticity in signaling pathways involved in motor recovery after spinal cord injury

JN Bilchak, G Caron, MP Côté - International journal of molecular …, 2021 - mdpi.com
Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that
greatly affect quality of life. While many pharmacological interventions have been explored …

Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator‐activated receptor gamma coactivator 1 alpha

H Su, H Luo, Y Wang, Q Zhao, Q Zhang, Y Zhu, L Pan… - Glia, 2024 - Wiley Online Library
Growing evidence has proven the efficacy of physical exercise in remyelination and motor
function performance after spinal cord injury (SCI). However, the molecular mechanisms of …

Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells

YD Teng, WL Liao, H Choi, D Konya… - Regenerative …, 2006 - Taylor & Francis
As data elucidating the complexity of spinal cord injury pathophysiology emerge, it is
increasingly being recognized that successful repair will probably require a multifaceted …

Dynamics of biomarkers across the stages of traumatic spinal cord injury-implications for neural plasticity and repair

T Begenisic, C Pavese, B Aiachini… - Restorative …, 2021 - content.iospress.com
Background: Traumatic spinal cord injury (SCI) is a complex medical condition causing
significant physical disability and psychological distress. While the adult spinal cord is …

Beneficial effects of melatonin combined with exercise on endogenous neural stem/progenitor cells proliferation after spinal cord injury

Y Lee, S Lee, SR Lee, K Park, Y Hong, M Lee… - International journal of …, 2014 - mdpi.com
Endogenous neural stem/progenitor cells (eNSPCs) proliferate and differentiate into
neurons and glial cells after spinal cord injury (SCI). We have previously shown that …

Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling

DH Hwang, HY Shin, MJ Kwon, JY Choi… - Journal of …, 2014 - Soc Neuroscience
Combining cell transplantation with activity-based rehabilitation is a promising therapeutic
approach for spinal cord repair. The present study was designed to investigate potential …