Siglecs in allergy and asthma
BS Bochner, JA O'Sullivan, AT Chang… - Molecular aspects of …, 2023 - Elsevier
The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …
range from being annoying to those that are life-threatening. Available treatments include …
Siglecs as potential targets of therapy in human mast cell-and/or eosinophil-associated diseases
JA O'Sullivan, BA Youngblood, RP Schleimer… - Seminars in …, 2023 - Elsevier
Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …
Discovery, function, and therapeutic targeting of Siglec-8
BA Youngblood, J Leung, R Falahati, J Williams… - Cells, 2020 - mdpi.com
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface
receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33 …
receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33 …
Non-canonical roles of Siglecs: Beyond sialic acid-binding and immune cell modulation
SS Siddiqui - Molecular Aspects of Medicine, 2023 - Elsevier
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are I-type lectins that bind with
sialic acid ligands (Sia). Most are expressed on the surface of leukocytes and are involved in …
sialic acid ligands (Sia). Most are expressed on the surface of leukocytes and are involved in …
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions
T Kiwamoto, N Kawasaki, JC Paulson… - Pharmacology & …, 2012 - Elsevier
Siglecs (sialic acid immunoglobulin-like lectins) are members of the immunoglobulin gene
family that contain sialoside binding N-terminal domains. They are cell surface proteins …
family that contain sialoside binding N-terminal domains. They are cell surface proteins …
Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells
Y Jia, H Yu, SM Fernandes, Y Wei… - Journal of Allergy and …, 2015 - Elsevier
Background Balanced activation and inhibition of the immune system ensures pathogen
clearance while avoiding hyperinflammation. Siglecs, sialic acid–binding proteins found on …
clearance while avoiding hyperinflammation. Siglecs, sialic acid–binding proteins found on …
Siglec‐8 on human eosinophils and mast cells, and Siglec‐F on murine eosinophils, are functionally related inhibitory receptors
BS Bochner - Clinical & Experimental Allergy, 2009 - Wiley Online Library
Siglecs (sialic acid‐binding, Ig‐like lectins) are a family of single‐pass transmembrane cell
surface proteins found predominantly on leucocytes. Their unique structural characteristics …
surface proteins found predominantly on leucocytes. Their unique structural characteristics …
High-affinity ligands of Siglec receptors and their therapeutic potentials
Sialic acids are one of the important constituents of glycoconjugates in the deuterostome
lineage of animals and microorganisms. Siglecs (Sialic acid-binding immunoglobulin like …
lineage of animals and microorganisms. Siglecs (Sialic acid-binding immunoglobulin like …
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
Abstract CD33-related Siglecs (CD33rSiglecs) are a family of sialic acid–recognizing lectins
on immune cells whose biologic functions are unknown. We studied in vivo functions of …
on immune cells whose biologic functions are unknown. We studied in vivo functions of …
[HTML][HTML] Advances in understanding and exploiting Siglec–glycan interactions
Z Jame-Chenarboo, TE Gray, MS Macauley - Current Opinion in Chemical …, 2024 - Elsevier
Sialic-acid-binding immunoglobulin-type lectins (Siglecs) are a family of cell-surface
immunomodulatory receptors that recognize sialic-acid-containing glycans. The majority of …
immunomodulatory receptors that recognize sialic-acid-containing glycans. The majority of …