Thrombogenicity of β2-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

M Jankowski, I Vreys, C Wittevrongel… - Blood, The Journal …, 2003 - ashpublications.org
We previously showed that β2-glycoprotein I (β2GPI)–dependent lupus anticoagulants (LAs)
form bivalent antigen-antibody complexes with high affinity for phospholipids; these …

Lupus‐like anticoagulant properties of murine monoclonal antibodies to β2‐glycoprotein I

J Arvieux, P Pouzol, B Roussel… - British journal of …, 1992 - Wiley Online Library
The lipid‐binding inhibitor of coagulation, β2‐glycoprotein I (β2GPI), has been shown to
form the antigen to which some autoantibodies against anionic phospholipids (aPL) are …

Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces

J Arnout, C Wittevrongel, M Vanrusselt… - Thrombosis and …, 1998 - thieme-connect.com
The precise mechanism by which Beta-2-glycoprotein I (β 2 GPI-) dependent lupus
anticoagulants lengthen phospholipid-dependent clotting reactions is still poorly …

Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids.

H Takeya, T Mori, EC Gabazza… - The Journal of …, 1997 - Am Soc Clin Investig
beta2-Glycoprotein I (beta2GPI), a plasma glycoprotein with phospholipid-binding property,
is known to be the actual target antigen for autoimmune type anticardiolipin antibodies …

dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activity of anti-β2-glycoprotein I autoantibodies

V Pengo, A Biasiolo, P Rampazzo… - Thrombosis and …, 1999 - thieme-connect.com
Anti-β 2-glycoprotein I (β 2-GPI) antibodies behave as classical Lupus Anticoagulants (LA),
as they inhibit phospholipid-dependent coagulation reactions and their activity disappears in …

[HTML][HTML] A simple method to discriminate between β2-glycoprotein I-and prothrombin-dependent lupus anticoagulants

MJA Simmelink, R Derksen, J Arnout… - Journal of Thrombosis and …, 2003 - Elsevier
Lupus anticoagulants (LAC) are a heterogeneous group of autoantibodies that prolong
phospholipid-dependent clotting assays. The autoantibodies that cause LAC activity are …

Anticoagulant activity of β2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies

M Galli, P Comfurius, T Barbui… - Thrombosis and …, 1992 - thieme-connect.com
Plasmas of 16 patients positive for both IgG anticardiolipin (aCL) antibodies and lupus
anticoagulant (LA) antibodies were subjected to adsorption with liposomes containing …

Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when β2-glycoprotein I is bound to a suitable surface

V Pengo, A Biasiolo, MG Fior - Thrombosis and haemostasis, 1995 - thieme-connect.com
The antiphospholipid antibodies (aPL) present in autoimmune disorders are associated with
thromboembolic episodes, and their binding to phospholipids (PL) is mediated by a plasma …

β2-glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model

A Arad, V Proulle, RA Furie, BC Furie… - Blood, The Journal of …, 2011 - ashpublications.org
Antiphospholipid syndrome is characterized by thrombosis, recurrent fetal loss, and the
presence of the lupus anticoagulant, anticardiolipin antibodies, or anti–β2-glycoprotein-1 …

[HTML][HTML] A two‐step coagulation test to identify antiβ2‐glycoprotein I lupus anticoagulants

V Pengo, A Biasiolo, C Pegoraro, S Iliceto - Journal of Thrombosis and …, 2004 - Elsevier
Lupus anticoagulants (LA) are immunoglobulins which inhibit phospholipid (PL)‐dependent
coagulation tests. LA are not specific, as they may reflect the presence of antibodies to …