[HTML][HTML] High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations
Background Children of aged fathers are at a higher risk of developing mental disorders.
Alterations in sperm DNA methylation have been implicated as a potential cause. However …
Alterations in sperm DNA methylation have been implicated as a potential cause. However …
Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development
V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
[HTML][HTML] Age-associated sperm DNA methylation patterns do not directly persist trans-generationally
Background The impact of aging on the sperm methylome is well understood. However, the
direct, subsequent impact on offspring and the role of altered sperm DNA methylation …
direct, subsequent impact on offspring and the role of altered sperm DNA methylation …
[HTML][HTML] Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility
Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It
is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.) …
is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.) …
[HTML][HTML] Age-related methylation changes in the human sperm epigenome
L Bernhardt, M Dittrich, A Prell, R Potabattula… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Advanced paternal age is associated with increased risks for reproductive and offspring
medical problems. Accumulating evidence suggests age-related changes in the sperm …
medical problems. Accumulating evidence suggests age-related changes in the sperm …
[HTML][HTML] Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment
Parental age at time of offspring conception is increasing in developed countries. Advanced
male age is associated with decreased reproductive success and increased risk of adverse …
male age is associated with decreased reproductive success and increased risk of adverse …
[HTML][HTML] Paternal germ line aging: DNA methylation age prediction from human sperm
Background The relationship between aging and epigenetic profiles has been highlighted in
many recent studies. Models using somatic cell methylomes to predict age have been …
many recent studies. Models using somatic cell methylomes to predict age have been …
Age-related changes in DNA methylation levels at CpG sites in bull spermatozoa and in vitro fertilization-derived blastocyst-stage embryos revealed by combined …
K Takeda, E Kobayashi, K Nishino, A Imai… - … of Reproduction and …, 2019 - jstage.jst.go.jp
Age-associated methylation changes in genomic DNA have been recently reported in
spermatozoa, and these changes can contribute to decline in fertility. In a previous study, we …
spermatozoa, and these changes can contribute to decline in fertility. In a previous study, we …
[HTML][HTML] Sperm epigenetics and aging
TG Jenkins, KI Aston, DT Carrell - Translational Andrology and …, 2018 - ncbi.nlm.nih.gov
Advanced paternal age has very real consequences in fertility, embryogenesis, and even
offspring health. Specifically, advanced paternal age has been linked to delayed time to …
offspring health. Specifically, advanced paternal age has been linked to delayed time to …
Genome-wide differential methylation analyses identifies methylation signatures of male infertility
STUDY QUESTION Do methylation changes in sperm DNA correlate with infertility? STUDY
ANSWER Loss of spermatogenesis and fertility was correlated with 1680 differentially …
ANSWER Loss of spermatogenesis and fertility was correlated with 1680 differentially …