[HTML][HTML] Conotoxins targeting nicotinic acetylcholine receptors: an overview
Marine snails of the genus Conus are a large family of predatory gastropods with an
unparalleled molecular diversity of pharmacologically active compounds in their venom …
unparalleled molecular diversity of pharmacologically active compounds in their venom …
[HTML][HTML] Neuronal nicotinic acetylcholine receptor modulators from cone snails
Marine cone snails are a large family of gastropods that have evolved highly potent venoms
for predation and defense. The cone snail venom has exceptional molecular diversity in …
for predation and defense. The cone snail venom has exceptional molecular diversity in …
Structure-activity studies on alpha-conotoxins
M Muttenthaler, KB Akondi… - Current pharmaceutical …, 2011 - ingentaconnect.com
Conotoxins are small bioactive highly structured peptides from the venom of marine cone
snails (genus Conus). Over the past 50 million years these molluscs have developed a …
snails (genus Conus). Over the past 50 million years these molluscs have developed a …
Alpha conotoxins nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads
JL Dutton, DJ Craik - Current medicinal chemistry, 2001 - ingentaconnect.com
a-Conotoxins are small disulfide rich peptides from the venoms of marine cone snails. They
target specific nicotinic acetylcholine receptor (nAChR) subtypes with high affinity and …
target specific nicotinic acetylcholine receptor (nAChR) subtypes with high affinity and …
Conotoxins: natural product drug leads
R Halai, DJ Craik - Natural product reports, 2009 - pubs.rsc.org
Covering: up to the end of 2008 Venomous marine cone snails harbour a variety of small
disulfide-rich peptides called conotoxins, which target a broad range of ion channels …
disulfide-rich peptides called conotoxins, which target a broad range of ion channels …
Conotoxins: Structure, therapeutic potential and pharmacological applications
R Mir, S Karim, M Amjad Kamal… - Current …, 2016 - ingentaconnect.com
Cone snails, also known as marine gastropods, from Conus genus produce in their venom a
diverse range of small pharmacologically active structured peptides called conotoxins. The …
diverse range of small pharmacologically active structured peptides called conotoxins. The …
Sodium channel toxins-receptor targeting and therapeutic potential
RJ French, H Terlau - Current medicinal chemistry, 2004 - ingentaconnect.com
Sodium channels underlie propagated electrical signalling in most excitable cells, including
neurons and the myocytes of skeletal muscle and heart. These proteins are targeted by a …
neurons and the myocytes of skeletal muscle and heart. These proteins are targeted by a …
[HTML][HTML] Conotoxins that confer therapeutic possibilities
M Essack, VB Bajic, JAC Archer - Marine drugs, 2012 - mdpi.com
Cone snails produce a distinctive repertoire of venom peptides that are used both as a
defense mechanism and also to facilitate the immobilization and digestion of prey. These …
defense mechanism and also to facilitate the immobilization and digestion of prey. These …
Drugs from the sea: conopeptides as potential therapeutics
BG Livett, KR Gayler, Z Khalil - Current medicinal chemistry, 2004 - ingentaconnect.com
Marine cone snails from the genus Conus are estimated to consist of up to 700 species.
These predatory molluscs have devised an efficient venom apparatus that allows them to …
These predatory molluscs have devised an efficient venom apparatus that allows them to …
Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters
RJ Lewis - IUBMB life, 2004 - Wiley Online Library
Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These
peptides are directed against a wide variety of pharmacological targets, making them an …
peptides are directed against a wide variety of pharmacological targets, making them an …