The brain accounts for around 2% of human adult bodyweight but consumes 20% of the
resting oxygen available to the whole body. The brain is dependent on a constant supply of …

The constant perfusion of a human organ with nutrients and oxygen demands a robust
regulatory mechanisms in the face of normal day-to-day pressure variations in the …

The dynamic cerebral blood flow response to sudden hypotension during posture change is
poorly understood. To better understand the cardiovascular response to hypotension, we …

The cerebral microvasculature plays a key role in the transport of blood and the delivery of
nutrients to the cells that perform brain function. Although recent advances in experimental …

Understanding the anatomy and hemodynamic relationships of the cerebral vasculature is
critical to an appreciation of the importance of these relationships in the control of the …

The human brain is possibly the most complex organ in existence. This complexity means
that it is capable of great feats, yet has ensured that it remains surprisingly poorly …

The construction of a computational model of the human brain circulation is described. We
combine an existing model of the biophysics of the circulatory system, a basic model of brain …

A mathematical model of the cerebral circulation has been formulated. It was based on non-
linear equations of pulsatile fluid flow in distensible conduits and applied to a network …

A computer model was developed to describe regional cerebral blood flow and tissue
oxygenation with autoregulation during focal ischemia produced by occlusion of th middle …

Nutrient delivery to the brain presents a unique challenge because the tissue functions as a
computer system with in the order of 200,000 neurons/mm 3. Penetrating arterioles bud from …