Complex Structures Made Simple–Continuous Flow Production of Core Cross‐Linked Polymeric Micelles for Paclitaxel Pro‐Drug‐Delivery
TA Bauer, J Schramm, F Fenaroli, S Siemer… - Advanced …, 2023 - Wiley Online Library
Translating innovative nanomaterials to medical products requires efficient manufacturing
techniques that enable large‐scale high‐throughput synthesis with high reproducibility …
techniques that enable large‐scale high‐throughput synthesis with high reproducibility …
Reduction-triggered release of paclitaxel from in situ formed biodegradable core-cross-linked micelles
W Zhu, Y Wang, X Cai, G Zha, Q Luo, R Sun… - Journal of Materials …, 2015 - pubs.rsc.org
Paclitaxel-loaded reduction-responsive core-crosslinked micelles were prepared in situ in
aqueous media via “click” chemistry. An amphiphilic block copolymer with multiple pendant …
aqueous media via “click” chemistry. An amphiphilic block copolymer with multiple pendant …
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications
Q Hu, CJF Rijcken, E van Gaal, P Brundel… - Journal of controlled …, 2016 - Elsevier
To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies
are needed in which physicochemical and pharmaceutical properties can be tailored …
are needed in which physicochemical and pharmaceutical properties can be tailored …
In situ fabrication of paclitaxel‐loaded core‐crosslinked micelles via thiol‐ene “click” chemistry for reduction‐responsive drug release
Y Huang, R Sun, Q Luo, Y Wang… - Journal of Polymer …, 2016 - Wiley Online Library
In this study, a facile method to fabricate reduction‐responsive core‐crosslinked micelles via
in situ thiol‐ene “click” reaction was reported. A series of biodegradable poly (ether‐ester) s …
in situ thiol‐ene “click” reaction was reported. A series of biodegradable poly (ether‐ester) s …
Redox-responsive, core-cross-linked micelles capable of on-demand, concurrent drug release and structure disassembly
We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are
subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of …
subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of …
Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges
T Ojha, Q Hu, C Colombo, J Wit… - Biotechnology …, 2021 - Wiley Online Library
Background CriPec technology enables the generation of drug‐entrapped biodegradable
core‐crosslinked polymeric micelles (CCPM) with high drug loading capacity, tailorable size …
core‐crosslinked polymeric micelles (CCPM) with high drug loading capacity, tailorable size …
Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery
Nanoscale drug delivery platforms have been developed over the past four decades that
have shown promising clinical results in several types of cancer and inflammatory disorders …
have shown promising clinical results in several types of cancer and inflammatory disorders …
Core-crosslinked pH-sensitive degradable micelles: a promising approach to resolve the extracellular stability versus intracellular drug release dilemma
The extracellular stability versus intracellular drug release dilemma has been a long
challenge for micellar drug delivery systems. Here, core-crosslinked pH-sensitive …
challenge for micellar drug delivery systems. Here, core-crosslinked pH-sensitive …
Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
M Talelli, M Barz, CJF Rijcken, F Kiessling… - Nano today, 2015 - Elsevier
Polymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs.
Many different PM have been designed and evaluated over the years, and some of them …
Many different PM have been designed and evaluated over the years, and some of them …
[HTML][HTML] Novel redox-responsive amphiphilic copolymer micelles for drug delivery: Synthesis and characterization
J Bae, A Maurya, Z Shariat-Madar, SN Murthy, S Jo - The AAPS journal, 2015 - Springer
A novel redox-responsive amphiphilic polymer was synthesized with bioreductive trimethyl-
locked quinone propionic acid for a potential triggered drug delivery application. The aim of …
locked quinone propionic acid for a potential triggered drug delivery application. The aim of …
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