Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

The presence of lactate in human tumours has been long neglected, confined to the role of a
waste product derived from glycolysis and as a biomarker of malignancy. More recently …

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a
larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of …

Metabolic reprogramming is one of fourteen hallmarks of tumor cells, among which aerobic
glycolysis, often known as the “Warburg effect,” is essential to the fast proliferation and …

The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …

Increased glucose uptake and accumulation of lactate, even under normoxic conditions (ie,
aerobic glycolysis or the Warburg Effect), is a common feature of cancer cells. This …

Fermentative glycolysis, an ancient evolved metabolic pathway, is exploited by rapidly
growing tissues and tumors but also occurs in response to the nutritional and energetic …