Selected ion monitoring for orbitrap-based metabolomics
Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …
[PDF][PDF] Selected Ion Monitoring for Orbitrap-Based Metabolomics. Metabolites 2024, 14, 184
Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …
Metabolite spectral accuracy on orbitraps
Orbitraps are high-resolution ion-trap mass spectrometers that are widely used in
metabolomics. While the mass accuracy and resolving power of orbitraps have been …
metabolomics. While the mass accuracy and resolving power of orbitraps have been …
[HTML][HTML] Minimizing ion competition boosts volatile metabolome coverage by secondary electrospray ionization orbitrap mass spectrometry
Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) is an
emerging technique for the detection of volatile metabolites. However, sensitivity and …
emerging technique for the detection of volatile metabolites. However, sensitivity and …
Evaluation of the high-field Orbitrap fusion for compound annotation in metabolomics
P Barbier Saint Hilaire, UM Hohenester… - Analytical …, 2018 - ACS Publications
Annotation of signals of interest represents a key point in mass spectrometry-based
metabolomics studies. The first level of investigation is the elemental composition, which can …
metabolomics studies. The first level of investigation is the elemental composition, which can …
Comparative evaluation of data dependent and data independent acquisition workflows implemented on an orbitrap fusion for untargeted metabolomics
P Barbier Saint Hilaire, K Rousseau, A Seyer… - Metabolites, 2020 - mdpi.com
Constant improvements to the Orbitrap mass analyzer, such as acquisition speed,
resolution, dynamic range and sensitivity have strengthened its value for the large-scale …
resolution, dynamic range and sensitivity have strengthened its value for the large-scale …
Influence of mass resolving power in orbital ion-trap mass spectrometry-based metabolomics
L Najdekr, D Friedecky, R Tautenhahn… - Analytical …, 2016 - ACS Publications
Modern separation methods in conjunction with high-resolution accurate mass (HRAM)
spectrometry can provide an enormous number of features characterized by exact mass and …
spectrometry can provide an enormous number of features characterized by exact mass and …
A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications
G Mullard, JW Allwood, R Weber, M Brown, P Begley… - Metabolomics, 2015 - Springer
The annotation and identification of metabolites is a current bottleneck in non-targeted
metabolomics studies. Although accurate measurement of m/z is applied routinely in UPLC …
metabolomics studies. Although accurate measurement of m/z is applied routinely in UPLC …
Characterization of the spectral accuracy of an orbitrap mass analyzer using isotope ratio mass spectrometry
S Khodjaniyazova, M Nazari, KP Garrard… - Analytical …, 2018 - ACS Publications
Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) source
coupled to the Q Exactive Plus has been extensively used in untargeted mass spectrometry …
coupled to the Q Exactive Plus has been extensively used in untargeted mass spectrometry …
Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions
Mass spectrometry based metabolomics is a widely used approach in biomedical research.
However, current methods coupling mass spectrometry with chromatography are time …
However, current methods coupling mass spectrometry with chromatography are time …