B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) blasts strictly depend on the
transport of extra‐cellular asparagine (Asn), yielding a rationale for L‐asparaginase …

L-asparaginase is an enzyme that causes hydrolysis of L-asparagine and L-glutamine,
leading to its reduction and, ultimately, depletion in peripheral blood and bone marrow. If …

To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used
cDNA microarrays to obtain a genome-wide view of gene expression both at baseline and …

L‐asparaginase (ASN ase) serves as an effective drug for adolescent acute lymphoblastic
leukemia. However, many clinical trials indicated severe ASN ase toxicity in patients with …

Mechanisms underlying the resistance of acute lymphoblastic leukemia (ALL) blasts to l-
asparaginase are still incompletely known. Here we demonstrate that human primary bone …

L-asparaginase (ASNase), the drug included on the World Health OrganizationLs list of
essential medicines, is irreplaceable in the front-line treatment of childhood acute …

Eradicating the malignant stem cell is the ultimate challenge in the treatment of leukaemia.
Leukaemic stem cells (LSC) hijack the normal haemopoietic niche, where they are mainly …

Abstract L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine
to L-aspartic acid, and its depletion induces leukemic cell death. L-Asp is an important …

Abstract Abstract 3641 Introduction: L-asparaginase (LA) in combination with other drugs
has been one of the standard components of acute lymphocytic leukemia (ALL) therapy for …

Introduction The rational of use of L-asparaginase (L-Aspa) is based on asparagine
synthetase (ASNS) deficiency in leukemic cells. Its efficacy is due to its capacity to deplete …