Blanken, P., Hendriks, VM, Huijsman, IA, van Ree, JM, van den Brink, W., 2016. Efficacy of
cocaine contingency management in heroin-assisted treatment: Results of a randomized …

Background Cocaine, particularly in its base form ('crack'), has become one of the drugs of
most concern in the Netherlands, being associated with a wide range of medical, psychiatric …

Background Crack-cocaine dependence is a complex disorder with limited treatment
options. Topiramate is one of the promising medications with reported reductions in cocaine …

Objective: We performed a double-blind, randomized, placebo-controlled trial to assess the
efficacy of topiramate in the treatment of crack cocaine dependence. Method: Sixty men who …

Introduction: There are no FDA-approved pharmacotherapies for treating cocaine addiction;
thus, developing drugs to treat cocaine dependence is an unmet critical need. Fortunately …

Aims To assess the efficacy of topiramate in treating cocaine use disorder (ie retention,
efficacy, safety and craving reduction) through a systematic review and meta‐analysis …

Abstract Background Topiramate increases GABAergic activity and antagonizes the
AMPA/kainate subtype of glutamate receptors. Through these mechanisms of action …

We read with interest Darke & Farrell's [1] commentary on our meta-analysis of topiramate
published in the eighth issue of 2016 [2]. To elaborate on some of the ideas raised by the …

Importance No medication has been established as an efficacious treatment for cocaine
dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine …

Purpose The literature on topiramate use in cocaine-dependent patients was reviewed.
Summary Six randomized, double-blind, controlled clinical trials evaluating the use of …