Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …

An additional copy of the β-amyloid precursor protein (APP) gene causes early-onset
Alzheimer's disease (AD) in trisomy 21 (DS). Endosome dysfunction develops very early in …

Altered neuronal endocytosis is the earliest known pathology in sporadic Alzheimer's
disease (AD) and Down syndrome (DS) brain and has been linked to increased Aβ …

Objective Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease
(AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and …

Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and
increased beta-amyloid (Aβ) peptide production underlie the universal development of …

Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the
leading genetic risk factor for Early-Onset AD, prematurely presenting the classic …

Intellectual disability in Down syndrome (DS) appears to be related to severe proliferation
impairment during brain development. Recent evidence shows that it is not only cellular …

Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly
attributed to an increased dosage of the amyloid precursor protein (APP) gene. To test this in …