Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)

MK Passarelli, N Winograd - … et Biophysica Acta (BBA)-Molecular and Cell …, 2011 - Elsevier
Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Lipid imaging with cluster time-of-flight secondary ion mass spectrometry

A Brunelle, O Laprévote - Analytical and bioanalytical chemistry, 2009 - Springer
This brief article provides an overview of the current state of the art in biological imaging
mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF …

Imaging lipids with secondary ion mass spectrometry

ML Kraft, HA Klitzing - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2014 - Elsevier
This review discusses the application of time-of-flight secondary ion mass spectrometry (TOF-
SIMS) and magnetic sector SIMS with high lateral resolution performed on a Cameca …

A new dynamic in mass spectral imaging of single biological cells

JS Fletcher, S Rabbani, A Henderson… - Analytical …, 2008 - ACS Publications
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has unique capabilities in the
area of high-resolution mass spectrometric imaging of biological samples. The technique …

MS/MS methodology to improve subcellular mapping of cholesterol using TOF-SIMS

PD Piehowski, AJ Carado, ME Kurczy… - Analytical …, 2008 - ACS Publications
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) can be utilized to map the
distribution of various molecules on a surface with submicrometer resolution. Much of its …

Secondary ion MS imaging to relatively quantify cholesterol in the membranes of individual cells from differentially treated populations

SG Ostrowski, ME Kurczy, TP Roddy… - Analytical …, 2007 - ACS Publications
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a well-established
bioanalytical method for directly imaging the chemical distribution across single cells. Here …

Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions

JS Fletcher, NP Lockyer… - Mass spectrometry …, 2011 - Wiley Online Library
In principle mass spectral imaging has enormous potential for discovery applications in
biology. The chemical specificity of mass spectrometry combined with spatial analysis …

[HTML][HTML] Advancements in ToF-SIMS imaging for life sciences

F Jia, X Zhao, Y Zhao - Frontiers in Chemistry, 2023 - frontiersin.org
In the last 2 decades, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has
gained significant prominence as a powerful imaging technique in the field of life sciences …

[HTML][HTML] Biological tissue sample preparation for time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging

S Yoon, TG Lee - Nano Convergence, 2018 - Springer
Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …

Time‐of‐flight secondary ion mass spectrometry imaging of biological samples with delayed extraction for high mass and high spatial resolutions

QP Vanbellingen, N Elie, MJ Eller… - Rapid …, 2015 - Wiley Online Library
Rationale In Time‐of‐Flight Secondary Ion Mass Spectrometry (TOF‐SIMS), pulsed and
focused primary ion beams enable mass spectrometry imaging, a method which is …