Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
[HTML][HTML] Genetic causes and modifiers of autism spectrum disorder
L Rylaarsdam, A Guemez-Gamboa - Frontiers in cellular …, 2019 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
[HTML][HTML] Translational approaches to the biology of Autism: false dawn or a new era?
C Ecker, W Spooren, DGM Murphy - Molecular psychiatry, 2013 - nature.com
Discovering novel treatments for Autism Spectrum Disorders (ASD) is a challenge. Its
etiology and pathology remain largely unknown, the condition shows wide clinical diversity …
etiology and pathology remain largely unknown, the condition shows wide clinical diversity …
Genetic heterogeneity in autism: From single gene to a pathway perspective
JY An, C Claudianos - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major
challenge. Recent advances in genetic screening and systems biology approaches have …
challenge. Recent advances in genetic screening and systems biology approaches have …
Autism spectrum disorders: from genes to neurobiology
AJ Willsey, MW State - Current opinion in neurobiology, 2015 - Elsevier
Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …
[HTML][HTML] Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive …
impairments in social interaction and communication and restricted and repetitive …
Autism spectrum disorder: insights into convergent mechanisms from transcriptomics
M Quesnel-Vallières, RJ Weatheritt, SP Cordes… - Nature Reviews …, 2019 - nature.com
Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic
variants have been defined only in a fairly small subset of cases. The enormous genetic …
variants have been defined only in a fairly small subset of cases. The enormous genetic …
[HTML][HTML] Lost in translation: traversing the complex path from genomics to therapeutics in autism spectrum disorder
N Sestan - Neuron, 2018 - cell.com
Recent progress in the genomics of non-syndromic autism spectrum disorder (nsASD)
highlights rare, large-effect, germline, heterozygous de novo coding mutations. This …
highlights rare, large-effect, germline, heterozygous de novo coding mutations. This …
Genetic modules for autism
B LaFlamme - Nature Genetics, 2015 - nature.com
Autism spectrum disorder (ASD) is genetically heterogeneous, with most ASD-associated
variants accounting for very few cases. Michael Snyder and colleagues used a systems …
variants accounting for very few cases. Michael Snyder and colleagues used a systems …
The emerging picture of autism spectrum disorder: genetics and pathology
JA Chen, O Peñagarikano, TG Belgard… - Annual Review of …, 2015 - annualreviews.org
Autism spectrum disorder (ASD) is defined by impaired social interaction and
communication accompanied by stereotyped behaviors and restricted interests. Although …
communication accompanied by stereotyped behaviors and restricted interests. Although …