The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4
(H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including …

In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a
posttranslational modification associated with actively transcribed genes. There is only one …

Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior
monoubiquitination of histone H2B. To define whether other residues within the histones are …

Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the
COMPASS (com plex of p roteins as sociated with S et1) family from Saccharomyces …

The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …

Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved
multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from …

Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …

Mono-ubiquitylation of histone H2B correlates with transcriptional activation and is required
for di-and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS …

Histone H2B monoubiquitination by Rad6/Bre1 is required for the trimethylation of both
histone H3K4 and H3K79 by COMPASS and Dot1 methyltransferases, respectively. The …