While the pathophysiological changes induced by the loss of dopamine innervation in the
basal ganglia by Parkinson's disease (PD) are well studied, little is known about functional …

Aging is the most prominent risk factor for Parkinson's disease. Yet, consensus of how
advancing age may predispose the dopamine (DA) system to parkinsonism is lacking. Three …

Degeneration of substantia nigra pars compacta dopamine neurons is a central feature in
the pathology of Parkinson's disease, which is characterized by progressive loss of motor …

Normal aging brings with it changes in dopaminergic and memory functions. However, little
is known about how these 2 changes are related. In this study, we identify a link between …

Abstract For these studies, young (8–9 years), middle‐aged (14–17 years) and aged (23–28
years) rhesus monkeys were used as a model of normal aging in humans to investigate …

Although the role of dopamine dysfunction is well established in Parkinson's disease, the
effect of nigrostriatal degeneration on motor performance during normal aging is less well …

The present study examined neurochemical, morphological and functional markers of the
nigrostriatal dopamine system in young, intermediate-aged and old squirrel monkeys …

In the present study, age‐related changes in the striatal dopaminergic system were
examined in the living brains of conscious young (6.2±1.5 years old) and aged (20.2±2.6 …

Changes in the mesostriatal dopamine system associated with normal aging are observed
in both human and laboratory animals, but the specific behavioral consequences of these …

Deterioration of motor function is a hallmark of senescence in humans and other mammalian
species. The similarity of age-related motor deterioration to the symptoms of Parkinson's …