CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma
Although tumors tend to be associated with immune cells and inflammation, this immune
response often fails to eliminate the cancer and instead promotes cancer progression …
response often fails to eliminate the cancer and instead promotes cancer progression …
[HTML][HTML] HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer
Y Liu, X Li, H Zhang, M Zhang, Y Wei - Oncogene, 2021 - nature.com
Despite the well-established role of CMTM6 in the stabilization of cell surface PD-L1 in
cancer cells, the mechanisms underlying CMTM6 expression and regulation are still largely …
cancer cells, the mechanisms underlying CMTM6 expression and regulation are still largely …
C/EBPα mediates the maturation and antitumor functions of macrophages in human hepatocellular carcinoma
Y Wang, Z Li, W Chen, J Wang, Z Huang, X Yu… - Cancer Letters, 2024 - Elsevier
Recent studies have suggested that therapeutic upregulation of CCAAT/enhancer binding
protein α (C/EBPα) prevents hepatocellular carcinoma (HCC) progression. However, the …
protein α (C/EBPα) prevents hepatocellular carcinoma (HCC) progression. However, the …
[HTML][HTML] Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth
D Shi, X Xiao, Y Tian, L Qin, F Xie, R Sun, J Wang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Activating enhancer-binding protein-2α (AP-2α) regulates the expression of many cancer-
related genes. Here, we demonstrated a novel mechanism by which AP-2α up-regulated …
related genes. Here, we demonstrated a novel mechanism by which AP-2α up-regulated …
[HTML][HTML] CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway
A Sato, N Yamada, Y Ogawa, M Ikegami - PLoS One, 2013 - journals.plos.org
The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) is a basic leucine
zipper transcription factor and is expressed in alveolar type II cells, alveolar macrophages …
zipper transcription factor and is expressed in alveolar type II cells, alveolar macrophages …
[HTML][HTML] Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer
Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and
spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of …
spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of …
Tumour YAP1 and PTEN expression correlates with tumour‐associated myeloid suppressor cell expansion and reduced survival in colorectal cancer
R Yang, T Cai, X Wu, Y Liu, J He, X Zhang, G Ma… - …, 2018 - Wiley Online Library
The expansion of myeloid‐derived suppressor cells (MDSCs) correlates with tumorigenesis
in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC …
in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC …
IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors
Macrophages in the tumor microenvironment respond to complex cytokine signals. How
these responses shape the phenotype of tumor-associated macrophages (TAMs) is …
these responses shape the phenotype of tumor-associated macrophages (TAMs) is …
[HTML][HTML] PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells
N Sheshadri, DK Poria, S Sharan, Y Hu, C Yan… - Cell death & …, 2021 - nature.com
Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and
conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response …
conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response …
[HTML][HTML] Downregulation of HuR inhibits the progression of esophageal cancer through interleukin-18
Purpose The purpose of this study was to investigate the effect of human antigen R (HuR)
downregulation and the potential target genes of HuR on the progression of esophageal …
downregulation and the potential target genes of HuR on the progression of esophageal …