Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …

Stroke is one of the leading causes of death worldwide with limited therapies. After ischemic
stroke occurs, a robust sterile inflammatory response happens and lasts for days and …

Stroke is a common disease with high mortality and disability worldwide. Different forms of
cell deaths, including apoptosis and necrosis, occur in ischemic or hemorrhagic brain tissue …

Stroke is a major cause of death and disability worldwide that triggers a variety of
neuropathological conditions, leading to the initiation of several pro-inflammatory mediators …

Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore,
we used the specific pyroptosis inhibitor Vx765 as an experimental intervention target in a …

Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability
worldwide. Recent evidence has proved that pyroptosis, a novel cell death form, contributes …

Stroke is an important disease that is prevalent worldwide [1–3]. Ischemic stroke accounts
for 80% of stroke cases. Currently, evidence-based effective treatments for ischemic stroke …

Ischemic stroke (IS) is one of the leading causes of death and disability. Its pathogenesis is
not completely clear, and inflammatory cascade is one of its main pathological processes …

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …

In addition to its profound implications in the fight against cancer, pyroptosis have important
role in the regulation of neuronal injury. Microglia are not only central members of the …