The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate
the intracellular signaling of cytokines in a wide spectrum of cellular processes. They …

ABSTRACT Introduction Tyrosine kinase 2 (TYK2) is a member of the JAK family class of
kinases that is responsible for mediating the immune response to IL-12, IL-23, and IFNα. The …

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in
mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 …

Abstract Tyrosine kinase 2 (TYK2), a key part of the Janus kinase-signal transducer and
activator of transcription (JAK-STAT) pathway, plays an integral role in the differentiation and …

JAKs are intracellular protein tyrosine kinases that, through activation of STATs, are
responsible for signal transduction pathways that regulate cellular responses to numerous …

JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in
treating complex diseases such as cancers and immune-mediated disorders. However, their …

Immune‐mediated chronic inflammatory diseases have emerged as a leading cause of
morbidity and mortality in Western countries over the last decades. Although multiple …

Abstract Tyrosine kinase 2 (TYK2) as a member of Janus kinase (JAK) family, mainly
mediates the signaling of type I interferons (IFN), interleukin-12 (IL-12) and interleukin-23 (IL …

Abstract Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family of intracellular
signalling molecules. By participating in signalling pathways downstream of type I …

Introduction: Tyrosine kinase 2 (Tyk2) is a Janus kinase family member that is crucial for
signaling transduction in response to a wide variety of cytokines, including type I IFNs, IL-6 …