Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells

N Akin, L von Mengden, AC Herta… - Biology of …, 2021 - academic.oup.com
In vitro maturation (IVM) is an assisted reproduction technique with reduced hormone-
related side-effects. Several attempts to implement IVM in routine practice have failed …

Effects of lactate, super-GDF9, and low oxygen tension during bi-phasic in vitro maturation on the bioenergetic profiles of mouse cumulus–oocyte complex

N Akin, G Ates, L von Mengden, AC Herta… - Biology of …, 2023 - academic.oup.com
In vitro maturation (IVM) is an alternative assisted reproductive technology with reduced
hormone-related side effects and treatment burden compared to conventional IVF …

Capacitation IVM improves cumulus function and oocyte quality in minimally stimulated mice

Y Zhao, X Liao, AE Krysta, MJ Bertoldo… - Journal of Assisted …, 2020 - Springer
Purpose Oocyte in vitro maturation (IVM) is a patient-friendly reproductive technology but
lower success rates than IVF have limited its uptake. Capacitation-IVM (CAPA-IVM) is an …

[HTML][HTML] Metabolic markers of developmental competence for in vitro-matured mouse oocytes

KA Preis, G Seidel, DK Gardner - Reproduction, 2005 - rep.bioscientifica.com
In vitro maturation of oocytes has enormous potential in assisted reproductive technology,
but its use has been limited due to insufficient knowledge of oocyte physiology during this …

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM

N Akin, D Richani, X Liao, Y Zhao, AC Herta… - Journal of Assisted …, 2022 - Springer
Purpose In vitro maturation (IVM) is a technology that generates mature oocytes following
culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by …

Failure to launch: aberrant cumulus gene expression during oocyte in vitro maturation

HM Brown, KR Dunning, M Sutton-McDowall… - …, 2017 - rep.bioscientifica.com
In vitro maturation (ivM) offers significant benefits for human infertility treatment and animal
breeding, but this potential is yet to be fully realised due to reduced oocyte developmental …

[HTML][HTML] Metabolomic profiles of bovine cumulus cells and cumulus-oocyte-complex-conditioned medium during maturation in vitro

K Uhde, HTA van Tol, TAE Stout, BAJ Roelen - Scientific reports, 2018 - nature.com
Cumulus cells are essential for nutrition of oocytes during maturation. In the absence of
cumulus cells during maturation, oocyte developmental competence is severely …

Prematuration with cyclic adenosine monophosphate modulators alters cumulus cell and oocyte metabolism and enhances developmental competence of in vitro …

HT Zeng, D Richani, ML Sutton-McDowall… - Biology of …, 2014 - academic.oup.com
Oocyte in vitro maturation (IVM) is an important assisted reproductive technology and
research tool. The adoption of IVM into routine clinical practice has been hindered by its …

[HTML][HTML] The pivotal role of glucose metabolism in determining oocyte developmental competence

ML Sutton-McDowall, RB Gilchrist… - Reproduction, 2010 - rep.bioscientifica.com
The environment that the cumulus oocyte complex (COC) is exposed to during either in vivo
or in vitro maturation (IVM) can have profound effects on the success of fertilisation and …

Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence

D Richani, KR Dunning, JG Thompson… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …