UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway

R Su, X Li, J Xiao, J Xu, J Tian, T Liu, Y Hu - Journal of Nanobiotechnology, 2024 - Springer
Abstract The Influenza A virus (IAV) is a zoonotic pathogen that infects humans and various
animal species. Infection with IAV can cause fever, anorexia, and dyspnea and is often …

Transcriptome profiling reveals differential effect of interleukin-17A upon influenza virus infection in human cells

J Li, K Zhang, W Fan, S Zhang, Y Li, J Gu… - Frontiers in …, 2019 - frontiersin.org
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and
pathways to promote replication and evade the host antiviral response. Identification of …

[HTML][HTML] Virus-like particle–mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

E Palermo, M Alexandridi, D Di Carlo… - Frontiers in Cellular …, 2022 - frontiersin.org
Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …

Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells

L Zhao, J Zhu, H Zhou, Z Zhao, Z Zou, X Liu, X Lin… - Scientific reports, 2015 - nature.com
Abstract H5N1 influenza A virus (IAV) causes severe respiratory diseases and high mortality
rates in animals and humans. MicroRNAs are being increasingly studied to evaluate their …

Silver nanoparticle based codelivery of oseltamivir to inhibit the activity of the H1N1 influenza virus through ROS-mediated signaling pathways

Y Li, Z Lin, M Zhao, T Xu, C Wang, L Hua… - … applied materials & …, 2016 - ACS Publications
As the therapeutic agent for antiviral applications, the clinical use of oseltamivir is limited
with the appearance of drug-resistant viruses. It is important to explore novel anti-influenza …

Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication

KV Chakravarthy, AC Bonoiu… - Proceedings of the …, 2010 - National Acad Sciences
The emergence of the pandemic 2009 H1N1 influenza virus has become a world-wide
health concern. As drug resistance appears, a new generation of therapeutic strategies will …

Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

U Rand, SY Kupke, H Shkarlet, MD Hein, T Hirsch… - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) emerged in late 2019 and resulted in a devastating pandemic …

A cell-based screening system for anti-influenza A virus agents

WY Wong, SW Loh, WL Ng, MC Tan, KS Yeo… - Scientific reports, 2015 - nature.com
Emerging of drug resistant influenza A virus (IAV) has been a big challenge for anti-IAV
therapy. In this study, we describe a relatively easy and safe cell-based screening system for …

Combined intranasal nanoemulsion and RIG-I activating RNA adjuvants enhance mucosal, humoral, and cellular immunity to influenza virus

PT Wong, PH Goff, RJ Sun, MJ Ruge… - Molecular …, 2020 - ACS Publications
Current influenza virus vaccines are focused on humoral immunity and are limited by the
short duration of protection, narrow cross-strain efficacy, and suboptimal immunogenicity …

[HTML][HTML] Interleukin 16 enhances the host susceptibility to influenza A virus infection

R Jia, C Jiang, L Li, C Huang, L Lu, M Xu, J Xu… - Frontiers in …, 2021 - frontiersin.org
Influenza A virus (IAV) is a major respiratory pathogen that causes seasonal and pandemic
flu, being a threat to global health. Various viral and cellular factors have been characterized …