Nebulization as a tool for photosensitizer delivery to the respiratory tract

G Kassab, MC Geralde, NM Inada… - Journal of …, 2019 - Wiley Online Library
To this day, any photosensitizers for the photodynamic treatment of pulmonary illnesses
have been administered intravenously. There is, however, an intrinsic difficulty in reaching …

Safety and delivery efficiency of a photodynamic treatment of the lungs using indocyanine green and extracorporeal near infrared illumination

G Kassab, V Cheburkanov, J Willis… - Journal of …, 2020 - Wiley Online Library
Photodynamic inactivation (PDI) is a promising alternative for combating infections caused
by antimicrobial resistant bacteria. Pneumonias are among the most worrisome infections …

Pneumonia treatment by photodynamic therapy with extracorporeal illumination‐an experimental model

MC Geralde, IS Leite, NM Inada… - Physiological …, 2017 - Wiley Online Library
Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the
increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is …

Drug and light delivery strategies for photodynamic antimicrobial chemotherapy (PACT) of pulmonary pathogens: a pilot study

CM Cassidy, MM Tunney, ND Magee, JS Elborn… - Photodiagnosis and …, 2011 - Elsevier
Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF) suffers,
with multidrug-resistant Pseudomonas aeruginosa and Burkholderia cepacia complex as …

Delivery of photosensitisers and light through mucus: investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic …

RF Donnelly, PA McCarron, CM Cassidy… - Journal of controlled …, 2007 - Elsevier
Respiratory disease is the main cause of morbidity and mortality in patients with cystic
fibrosis (CF). In such patients chronic Pseudomonas aeruginosa infection is virtually …

Photodynamic inactivation of Streptococcus pneumoniae with external illumination at 808 nm through the ex vivo porcine thoracic cage

JS Diaz Tovar, G Kassab, HH Buzzá… - Journal of …, 2022 - Wiley Online Library
Pneumonia is responsible for high mortality rates around the world, and its major treatment
is based on antibiotic treatment. Antimicrobial resistance has been increasing in the last …

Lung surfactant negatively affects the photodynamic inactivation of bacteria—in vitro and molecular dynamic simulation analyses

G Kassab, JS Diaz Tovar, LMP Souza… - Proceedings of the …, 2022 - National Acad Sciences
In the context of the rapid increase of antibiotic-resistant infections, in particular of
pneumonia, antimicrobial photodynamic therapy (aPDT), the microbiological application of …

[HTML][HTML] Aerosol-based antimicrobial photoinactivation in the lungs: an action spectrum study

C Treghini, A Dell'Accio, F Fusi, G Romano - … & Photobiological Sciences, 2021 - Springer
Chronic lung infections are among the most diffused human infections, being often
associated with multidrug-resistant bacteria. In this framework, the European project …

Near–infrared photodynamic inactivation of S. pneumoniae and its interaction with RAW 264.7 macrophages

IS Leite, MC Geralde, ACG Salina… - Journal of …, 2018 - Wiley Online Library
Pneumonia is the main cause of children mortality worldwide, and its major treatment
obstacle stems from the microorganisms increasing development of resistance to several …

Photodynamic therapy: where do we go from here?

D Moro-Sibilot, C Brambilla - European Respiratory Journal, 2003 - Eur Respiratory Soc
Photodynamic therapy (PDT) involves the use of photosensitising agents that are selectively
retained within tumour cells. The agents remain inactive until exposed to light of the proper …