Gut microbiome in modulating immune checkpoint inhibitors

X Li, S Zhang, G Guo, J Han, J Yu - EBioMedicine, 2022 - thelancet.com
Gut microbiome has been increasingly recognized for its influence on a diverse array of
human diseases including cancer, and may also influence the outcome of cancer therapies …

Gut microbiota in cancer immune response and immunotherapy

CB Zhou, YL Zhou, JY Fang - Trends in cancer, 2021 - cell.com
The gastrointestinal tract (GIT) is the largest immune organ and maintains systemic immune
homeostasis in the presence of bacterial challenge. Immune elimination and immune …

Gut microbiome as a potential factor for modulating resistance to cancer immunotherapy

L Shui, X Yang, J Li, C Yi, Q Sun, H Zhu - Frontiers in Immunology, 2020 - frontiersin.org
Gut microbiota refers to the diverse community of more than 100 trillion microorganisms
residing in our intestines. It is now known that any shift in the composition of gut microbiota …

Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors

S Rezasoltani, A Yadegar… - Cancer …, 2021 - Wiley Online Library
The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in
preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut …

Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors

RC Simpson, ER Shanahan, RA Scolyer… - Nature Reviews Clinical …, 2023 - nature.com
The gut microbiota modulates immune processes both locally and systemically. This
includes whether and how the immune system reacts to emerging tumours, whether …

[HTML][HTML] Gut microbiome and cancer immunotherapy

W Li, Y Deng, Q Chu, P Zhang - Cancer letters, 2019 - Elsevier
Microbiome is becoming crucial in that the balance between human health and disease can
be mediated by the gut microbiome. The gut microbiome can modulate the host immune …

The gut microbiome and efficacy of cancer immunotherapy

G Roviello, LF Iannone, M Bersanelli, E Mini… - Pharmacology & …, 2022 - Elsevier
Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented
improvement in overall and progression-free survival in several advanced and metastatic …

Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer

E Hayase, RR Jenq - Genome medicine, 2021 - Springer
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory
pathways. Administration of ICIs augments T cell-mediated immune responses against …

Fine-tuning cancer immunotherapy: optimizing the gut microbiome

JM Pitt, M Vétizou, N Waldschmitt, G Kroemer… - Cancer research, 2016 - AACR
The equilibrium linking the intestinal microbiota, the intestinal epithelium, and the host
immune system establishes host health and homeostasis, with perturbations of this balance …