[HTML][HTML] The safety and anti-ageing effects of nicotinamide mononucleotide in human clinical trials: an update

Q Song, X Zhou, K Xu, S Liu, X Zhu, J Yang - Advances in nutrition, 2023 - Elsevier
The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …

[HTML][HTML] Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects

K Okabe, K Yaku, Y Uchida, Y Fukamizu, T Sato… - Frontiers in …, 2022 - frontiersin.org
Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD+ precursor that has
demonstrated beneficial effects against aging and aging-associated diseases in animal …

[HTML][HTML] Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older …

M Igarashi, Y Nakagawa-Nagahama, M Miura… - npj Aging, 2022 - nature.com
Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide
(NAD+) upon the administration of nicotinamide mononucleotide (NMN), an NAD+ …

[HTML][HTML] Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Y Fukamizu, Y Uchida, A Shigekawa, T Sato… - Scientific reports, 2022 - nature.com
A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an
essential coenzyme for metabolic activity, causes various age-related diseases and …

[HTML][HTML] Nicotinamide mononucleotide (NMN) as an anti-aging health product–promises and safety concerns

H Nadeeshani, J Li, T Ying, B Zhang, J Lu - Journal of advanced research, 2022 - Elsevier
Background Elderly population has been progressively rising in the world, thus the demand
for anti-aging heath products to assure longevity as well as to ameliorate age-related …

The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

M Soma, SK Lalam - Molecular biology reports, 2022 - Springer
Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD+) has recently
gained a lot of attention. A systemic decline in NAD+ across many tissues is associated with …

[HTML][HTML] The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind …

L Yi, AB Maier, R Tao, Z Lin, A Vaidya, S Pendse… - Geroscience, 2023 - Springer
In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases
nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and …

[HTML][HTML] Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice

KF Mills, S Yoshida, LR Stein, A Grozio, S Kubota… - Cell metabolism, 2016 - cell.com
NAD+ availability decreases with age and in certain disease conditions. Nicotinamide
mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ …

[HTML][HTML] Dietary supplementation with NAD+-boosting compounds in humans: Current knowledge and future directions

KA Freeberg, CAC Udovich, CR Martens… - The Journals of …, 2023 - ncbi.nlm.nih.gov
Advancing age and many disease states are associated with declines in nicotinamide
adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ …

[HTML][HTML] Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment

ES Hwang, SB Song - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …