Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature
of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin …

Gastric inhibitory polypeptide receptor (GIPR) directly induces energy accumulation in
adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on …

Estrogen is an important regulator of metabolic syndrome, a collection of abnormalities
including obesity, insulin resistance/glucose intolerance, hypertension, dyslipidemia, and …

Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in
adipocytes. Inhibition of GIP signaling prevents onset of obesity and increases fat oxidation …

Context: Glucose-dependent insulinotropic peptide (GIP) has a central role in glucose
homeostasis through its amplification of insulin secretion; however, its physiological role in …

Background & Aims: In addition to its role as the primary mediator of the enteroinsular axis,
glucose-dependent insulinotropic polypeptide (GIP) may play a critical role in the …

Emerging evidence indicates that G-protein coupled receptor 55 (GPR55), a nonclassic
receptor of the endocannabinoid system that is activated by L-α-lysophosphatidylinositol …

The intestinal microbiome can regulate host energy homeostasis and the development of
metabolic disease. Here we identify GPR43, a receptor for bacterially produced short-chain …

Insulin resistance (IR) is considered to be one of the most important pathogenesis of
glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is …

OBJECTIVE—Progranulin is an important molecule in inflammatory response. Chronic
inflammation is frequently associated with central obesity and associated disturbances; …