Iron acquisition is critical for pathogenic fungi to adapt to and survive within the host
environment. However, to same extent, the fungi must also avoid the detrimental effects …

The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …

The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …

The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …

Highlights•C. neoformans possesses high-affinity and low-affinity iron uptake systems.•The
reductive high-affinity iron uptake system is required for virulence.•The regulation of iron …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Iron is an essential element to most microorganisms, yet an excess of iron is toxic. Hence,
living cells have to maintain a tight balance between iron uptake and iron consumption and …

Iron acquisition is essential for the proliferation of microorganisms, and human pathogens
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …