Coordinated regulation of iron metabolism in Cryptococcus neoformans by GATA and CCAAT transcription factors: connections with virulence
WH Jung, E Sánchez-León, JW Kronstad - Current genetics, 2021 - Springer
Iron acquisition is critical for pathogenic fungi to adapt to and survive within the host
environment. However, to same extent, the fungi must also avoid the detrimental effects …
environment. However, to same extent, the fungi must also avoid the detrimental effects …
[HTML][HTML] HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans
The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …
The monothiol glutaredoxin Grx4 regulates iron homeostasis and virulence in Cryptococcus neoformans
The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …
[PDF][PDF] The monothiol glutaredoxin Grx4 regulates iron homeostasis and virulence in Cryptococcus neoformans. mBio 9: e02377-18
The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …
An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans
JW Kronstad, G Hu, WH Jung - Trends in microbiology, 2013 - cell.com
Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …
Iron‐regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans
T Lian, MI Simmer, CA D'Souza, BR Steen… - Molecular …, 2005 - Wiley Online Library
Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …
Iron acquisition in the human fungal pathogen Cryptococcus neoformans
Highlights•C. neoformans possesses high-affinity and low-affinity iron uptake systems.•The
reductive high-affinity iron uptake system is required for virulence.•The regulation of iron …
reductive high-affinity iron uptake system is required for virulence.•The regulation of iron …
[HTML][HTML] Iron source preference and regulation of iron uptake in Cryptococcus neoformans
The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …
must compete with host proteins such as transferrin for iron. Iron regulation of gene …
The regulation of iron homeostasis in the fungal human pathogen Candida glabrata
F Devaux, A Thiébaut - Microbiology, 2019 - microbiologyresearch.org
Iron is an essential element to most microorganisms, yet an excess of iron is toxic. Hence,
living cells have to maintain a tight balance between iron uptake and iron consumption and …
living cells have to maintain a tight balance between iron uptake and iron consumption and …
Connecting iron regulation and mitochondrial function in Cryptococcus neoformans
LC Horianopoulos, JW Kronstad - Current opinion in microbiology, 2019 - Elsevier
Iron acquisition is essential for the proliferation of microorganisms, and human pathogens
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …
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