The dysregulated sepsis-induced cytokine storm evoked during systemic infection consists
of biphasic and interconnected pro-and anti-inflammatory responses. The contrasting …

Natural killer (NK) cells have the dual ability to produce pro-inflammatory (IFNγ) and anti-
inflammatory (IL-10) cytokines during systemic infection, which points to their crucial role …

Interleukin 15 is essential for the development and differentiation of NK and memory
CD8+(mCD8+) T cells. Our laboratory previously showed that NK and CD8+ T lymphocytes …

Sepsis, a disease of divergent pro-and anti-inflammatory–mediated pathways, has a high
prevalence of morbidity and mortality, yet an understanding of potential unifying mediators …

Interleukin (IL)-10 is an anti-inflammatory cytokine known to modulate the outcome of sepsis
by decreasing pro-inflammatory cytokine production, including IL-12, a main activator of …

Sepsis is a syndrome involving systemic inflammation as well as an infectious focus.
Accordingly, the host immune response to sepsis involves complex leukocyte interplay that …

A role for NKT cells has been implicated in sepsis, but the mechanism by which NKT cells
contribute to sepsis remains unclear. Here, we examined WT and NKT‐cell‐deficient mice of …

Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple
actions affecting the innate immune system as well as humoral and cellular immune …

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies.
A better understanding of the complex modifications of the immune system of septic patients …

As part of the innate immune system, human NK cells play a critical role early in the systemic
host defense against pathogens and tumor cells. Recent studies suggest a more complex …