Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the
mechanism is unclear. Activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) …

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol
(ALP), on cardiac dysfunction, oxidative‐nitrosative stress, apoptosis, poly (ADP‐ribose) …

MG-132, a proteasome inhibitor, can upregulate nuclear factor (NF) erythroid 2-related factor
2 (Nrf2)-mediated antioxidative function and downregulate NF-κB-mediated inflammation …

Nuclear factor-erythroid factor 2–related factor 2 (Nrf2) may either ameliorate or worsen
diabetic cardiomyopathy. However, the underlying mechanisms are poorly understood …

Luteolin has been reported to attenuate ischemia/reperfusion (I/R) injury in the diabetic heart
through endothelial nitric oxide synthase-(eNOS-) related antioxidative response. Though …

Hyperglycemia induces chronic inflammation and oxidative stress in cardiomyocyte, which
are the main pathological changes of diabetic cardiomyopathy (DCM). Treatment aimed at …

Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac
oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate …

Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts
in myocardial substrate preference, oxidative stress, and apoptosis. The protective …

OBJECTIVE Oxidative stress is implicated in cardiac insulin resistance, a critical risk factor
for cardiac failure, but the direct evidence remains missing. This study explored a causal link …

Diabetes causes lipid peroxide to accumulate within cardiomyocytes. Furthermore, lipid
peroxide buildup is a risk factor for ferroptosis. This study is aimed at examining whether …