[HTML][HTML] Leveraging antibody, B cell and Fc receptor interactions to understand heterogeneous immune responses in tuberculosis

SM Carpenter, LL Lu - Frontiers in immunology, 2022 - frontiersin.org
Despite over a century of research, Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis (TB), continues to kill 1.5 million people annually. Though less than 10% of …

[HTML][HTML] It takes a village: the multifaceted immune response to Mycobacterium tuberculosis infection and vaccine-induced immunity

SE Larsen, BD Williams, M Rais, RN Coler… - Frontiers in …, 2022 - frontiersin.org
Despite co-evolving with humans for centuries and being intensely studied for decades, the
immune correlates of protection against Mycobacterium tuberculosis (Mtb) have yet to be …

[PDF][PDF] A functional role for antibodies in tuberculosis

LL Lu, AW Chung, TR Rosebrock, M Ghebremichael… - Cell, 2016 - cell.com
While a third of the world carries the burden of tuberculosis, disease control has been
hindered by a lack of tools, including a rapid, point-of-care diagnostic and a protective …

Friends and foes of tuberculosis: modulation of protective immunity

S Brighenti, SA Joosten - Journal of internal medicine, 2018 - Wiley Online Library
Protective immunity in tuberculosis (TB) is subject of debate in the TB research community,
as this is key to fully understand TB pathogenesis and to develop new promising tools for TB …

[PDF][PDF] The immune landscape in tuberculosis reveals populations linked to disease and latency

E Esaulova, S Das, DK Singh, JA Choreno-Parra… - Cell host & …, 2021 - cell.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells

JK Sia, M Georgieva… - Journal of immunology …, 2015 - Wiley Online Library
Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis

MP Etna, E Giacomini, M Severa, EM Coccia - Seminars in immunology, 2014 - Elsevier
A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

[HTML][HTML] B-cells and antibodies as contributors to effector immune responses in tuberculosis

WF Rijnink, THM Ottenhoff, SA Joosten - Frontiers in immunology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to
mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB …

B in TB: B cells as mediators of clinically relevant immune responses in tuberculosis

M Rao, D Valentini, T Poiret, E Dodoo… - Clinical Infectious …, 2015 - academic.oup.com
The protective role of B cells and humoral immune responses in tuberculosis infection has
been regarded as inferior to cellular immunity directed to the intracellular pathogen …

[HTML][HTML] Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

P Sankar, BB Mishra - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to
1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium …