Nicotine-induced ILF2 facilitates nuclear mRNA export of pluripotency factors to promote stemness and chemoresistance in human esophageal cancer

Y Li, M Wang, M Yang, Y Xiao, Y Jian, D Shi, X Chen… - Cancer Research, 2021 - AACR
Balancing mRNA nuclear export kinetics with its nuclear decay is critical for mRNA
homeostasis control. How this equilibrium is aberrantly disrupted in esophageal cancer to …

Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem‐like cells

Z Liu, S Shan, Z Yuan, F Wu, M Zheng, Y Wang… - EMBO …, 2023 - embopress.org
While previous studies have identified cancer stem‐like cells (CSCs) as a crucial driver for
chemoresistance and tumor recurrence, the underlying mechanisms for populating the CSC …

HnRNPA2B1 ISGylation Regulates m6A‐Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development

T Jin, L Yang, C Chang, H Luo, R Wang… - Advanced …, 2024 - Wiley Online Library
Regulating nuclear export precisely is essential for maintaining mRNA homeostasis and
impacts tumor progression. However, the mechanisms governing nuclear mRNA export …

Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling

L Wang, L Du, X Xiong, Y Lin, J Zhu, Z Yao, S Wang… - Oncogene, 2021 - nature.com
Smoking is one of the most impactful lifestyle-related risk factors in many cancer types
including esophageal squamous cell carcinoma (ESCC). As the major component of …

Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells

Y Zhang, T Pan, X Zhong, C Cheng - Tumor Biology, 2014 - Springer
A consistent positive association between cigarette smoking and the human esophageal
cancer has been confirmed all over the world. However, details in the association need to be …

[HTML][HTML] linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A …

GW Huang, QQ Chen, CC Ma, LH Xie, J Gu - The International Journal of …, 2021 - Elsevier
Evidence shows that long noncoding RNAs (lncRNAs) modulate mRNAs of multiple genes
by post-transcriptional regulation. However, in esophageal squamous cell carcinoma …

Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy

D Xia, XR Zhang, YL Ma, ZJ Zhao, R Zhao, YY Wang - Cell & bioscience, 2020 - Springer
Background NF-E2-related factor 2 (Nrf2) is involved in the radiation resistance of
esophageal squamous cell carcinoma (ESCC), but the underlying molecular mechanism is …

FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA

K Wang, Z Mei, M Zheng, X Liu, D Li, H Wang - Heliyon, 2024 - cell.com
The role of fat mass and obesity-associated protein (FTO), an N 6-methyladenosine (m 6 A)
demethylase, in non-small cell lung cancer (NSCLC) has recently received widespread …

[PDF][PDF] SIDT2 RNA transporter promotes lung and gastrointestinal tumor development

TA Nguyen, KT Bieging-Rolett, TL Putoczki, IP Wicks… - Iscience, 2019 - cell.com
RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are
transported into lysosomes for degradation. This process involves the transmembrane …

CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells

PP Praharaj, S Patra, SR Mishra, S Mukhopadhyay… - Autophagy, 2023 - Taylor & Francis
Mitophagy regulates cancer stem cell (CSC) populations affecting tumorigenicity and
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …