Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE),
and this is thought to be a primary mechanism mediating the neurotoxicity of these …

Organophosphates (OPs) are a group of synthetic compounds that are neurotoxic in humans
and preclinical models. The canonical mechanism of OP neurotoxicity is inhibition of …

The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of
acetylcholinesterase (AChE). However, multiple lines of evidence suggest that mechanisms …

Organophosphorus (OPs) compounds are widely used as insecticides, plasticizers, and fuel
additives. These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that …

Organophosphate (OP) nerve agents exert their toxicity through inhibition of
acetylcholinesterase. The excessive stimulation of cholinergic receptors rapidly causes …

The term organophosphate (OP) refers to a diverse group of chemicals that are found in
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …

The translational capacity of data generated in preclinical toxicological studies is contingent
upon several factors, including the appropriateness of the animal model. The primary …

Background Acute intoxication with organophosphorus (OP) cholinesterase inhibitors can
trigger convulsions that progress to life-threatening status epilepticus. Survivors face long …

Organophosphates (OPs) are commonly used pesticides worldwide. Humans are exposed
to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal …

The differential inhibition of the target esterases acetylcholinesterase (AChE) and
neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds …