Gram-negative facultative anaerobes often cause bacteremia, a systemic infection
associated with severe clinical outcomes. ArcAB, a two-component regulatory system that …

Overflow metabolism in the presence of oxygen occurs at fast growth rates in a wide range
of organisms including bacteria, yeast and cancer cells and plays an important role in …

Abstract Background Hydrogen peroxide (H 2 O 2) is a reactive oxygen species (ROS),
which is part of the oxidative burst encountered upon internalization of Salmonella enterica …

ArcAB, also known as the Arc system, is a member of the two-component system family of
bacterial transcriptional regulators and is composed of sensor kinase ArcB and response …

Abstract Background The Arc two-component system is a global regulator controlling many
genes involved in aerobic/anaerobic respiration and fermentative metabolism in Escherichia …

Despite the importance of maintaining redox homeostasis for cellular viability, how cells
control redox balance globally is poorly understood. Here we provide new mechanistic …

Abstract Background Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-
negative pathogen that must successfully adapt to the broad fluctuations in the concentration …

Avian pathogenic Escherichia coli (APEC) is one of the common extraintestinal infectious
disease pathogens in chickens, geese, and other birds, inducing serious impediments to the …

Avian pathogenic Escherichia coli (APEC) strains cause one of the three most significant
infectious diseases in the poultry industry and are also potential food-borne pathogens …

Even though transcriptional regulation plays a key role in establishing the metabolic
network, the extent to which it actually controls the in vivo distribution of metabolic fluxes …