[HTML][HTML] Shen Qi Wan ameliorates learning and memory impairment induced by STZ in AD rats through PI3K/AKT pathway
J Huang, Z Xu, H Chen, Y Lin, J Wei, S Wang, H Yu… - Brain Sciences, 2022 - mdpi.com
Alzheimer's disease is the most common form of neurodegenerative disease, and increasing
evidence shows that insulin signaling has crucial roles in AD initiation and progression. In …
evidence shows that insulin signaling has crucial roles in AD initiation and progression. In …
Silibinin ameliorates STZ-induced impairment of memory and learning by up-regulating insulin signaling pathway and attenuating apoptosis
P Liu, L Cui, B Liu, W Liu, T Hayashi, K Mizuno… - Physiology & …, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease, mainly characterized by cognitive
dysfunction and memory impairment. Due to its pathological similarities to type 2 diabetes …
dysfunction and memory impairment. Due to its pathological similarities to type 2 diabetes …
[HTML][HTML] Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice
SJ Zhang, TT Xu, L Li, YM Xu, ZL Qu, XC Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate
cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an …
cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an …
Mitochondrial protection and against glutamate neurotoxicity via Shh/Ptch1 signaling pathway to ameliorate cognitive dysfunction by Kaixin San in multi‐infarct …
X Li, W Wen, P Li, Y Fu, H Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
Multi‐infarct dementia (MID), a prominent subtype of vascular dementia (VD), is responsible
for at least 15 to 20 percent of dementia in the elderly. Mitochondrial dysfunctions and …
for at least 15 to 20 percent of dementia in the elderly. Mitochondrial dysfunctions and …
Qingxin kaiqiao recipe improves cognitive performance, inhibits apoptosis, and reduces pathological deposits in APP/PS1 double transgenic mice via the PI3K/Akt …
SY Lin, TQ Wang, LT Xu, XX Lai, Y Shen… - Evidence‐Based …, 2020 - Wiley Online Library
The traditional Chinese medicine of Qingxin Kaiqiao Recipe (QKR) is effective in the
treatment of Alzheimer's disease (AD). This study aims to investigate whether QKR improves …
treatment of Alzheimer's disease (AD). This study aims to investigate whether QKR improves …
Neuroprotective Effects of ZiBuPiYin Recipe on db/db Mice via PI3K‐Akt Signaling Pathway by Activating Grb2
W Ren, Z Weng, X Li, L Zhan - Neural Plasticity, 2021 - Wiley Online Library
Background. Diabetes‐associated cognitive decline (DACD) is one of the nervous system
dysfunctions induced by diabetes mellitus with cognitive impairment as the major symptom …
dysfunctions induced by diabetes mellitus with cognitive impairment as the major symptom …
Classic famous prescription kai-xin-san ameliorates alzheimer's disease via the wnt/β-catenin signaling pathway
X Shan, S Lv, P Huang, W Zhang, C Jin, Y Liu… - Molecular …, 2024 - Springer
Abstract Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix,
Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective …
Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective …
Shenzhiling oral solution promotes myelin repair through PI3K/Akt-mTOR pathway in STZ-induced SAD mice
G Qin, Y Wang, Z Liu, L Mana, S Huang, P Wang - 3 Biotech, 2021 - Springer
Most forms of Alzheimer's disease are sporadic. A model of sporadic Alzheimer's disease
induced with bilateral intraventricular injection of streptozotocin leads to insulin resistance in …
induced with bilateral intraventricular injection of streptozotocin leads to insulin resistance in …
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice
X Peng, L Chen, Z Wang, Y He, JB Ruganzu… - European Journal of …, 2022 - Elsevier
Our previous findings indicated that tanshinone IIA (tan IIA), a natural component extracted
from the root and rhizome of danshen, significantly attenuated β-amyloid accumulation …
from the root and rhizome of danshen, significantly attenuated β-amyloid accumulation …
Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice
F Chen, Y He, P Wang, P Wei, H Feng… - International …, 2018 - journals.sagepub.com
Reduced glucose utilization and deficient energy metabolism that occur in the early stages
of Alzheimer's disease correlate with impaired cognition, and this information is evidence …
of Alzheimer's disease correlate with impaired cognition, and this information is evidence …