Modulating dopamine signaling and behavior with chemogenetics: concepts, progress, and challenges
AH Runegaard, CM Fitzpatrick, DPD Woldbye… - Pharmacological …, 2019 - ASPET
For more than 60 years, dopamine (DA) has been known as a critical modulatory
neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions …
neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions …
[HTML][HTML] Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action
A Ozawa, H Arakawa - Behavioural brain research, 2021 - Elsevier
Recent developments in chemogenetic approaches to the investigation of brain function
have ushered in a paradigm change in the strategy for drug and behavior research and …
have ushered in a paradigm change in the strategy for drug and behavior research and …
[HTML][HTML] An intersectional approach to target neural circuits with cell-and projection-type specificity: validation in the mesolimbic dopamine system
N Kakava-Georgiadou, MM Zwartkruis… - Frontiers in Molecular …, 2019 - frontiersin.org
Development of tools to manipulate activity of specific neurons is important for dissecting the
function of neural circuits. Viral vectors and conditional transgenic animal lines that target …
function of neural circuits. Viral vectors and conditional transgenic animal lines that target …
Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems
A major focus in studying the progression and prevention of addictive diseases has been to
understand the molecular and cellular mechanisms underlying drug addiction. The brain …
understand the molecular and cellular mechanisms underlying drug addiction. The brain …
Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience
J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …
Chemogenetic signaling in space and time: considerations for designing neuroscience experiments using DREADDs
The use of designer receptors exclusively activated by designer drugs (DREADDs) has led
to significant advances in our understanding of the neural circuits that govern behavior. By …
to significant advances in our understanding of the neural circuits that govern behavior. By …
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Y Nagai, N Miyakawa, H Takuwa, Y Hori… - Nature …, 2020 - nature.com
The chemogenetic technology designer receptors exclusively activated by designer drugs
(DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and …
(DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and …
Chemogenetics for cell-type-specific modulation of signalling and neuronal activity
Chemogenetics is an approach for engineering proteins to enable their modulation by
otherwise inert small molecules. Although kinases, enzymes and ion channels have been …
otherwise inert small molecules. Although kinases, enzymes and ion channels have been …
The use of chemogenetic approaches in alcohol use disorder research and treatment
Several novel techniques were developed recently to explore neural circuit mechanisms of
neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively …
neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively …
[PDF][PDF] Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders
Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …