In Vitro Interaction between Isavuconazole and Tacrolimus, Cyclosporin A, or Sirolimus against Aspergillus Species

P Schwarz, E Dannaoui - Journal of Fungi, 2020 - mdpi.com
The interaction of isavuconazole with immunosuppressors (tacrolimus, cyclosporin A, or
sirolimus) against 30 Aspergillus isolates belonging to the most common species …

Multicenter Italian Study on “In Vitro Activities” of Isavuconazole, Voriconazole, Amphotericin B, and Caspofungin for Aspergillus Species: Comparison between SensititreTM …

G Lo Cascio, A Bazaj, L Trovato, S Sanna… - Infection and Drug …, 2022 - Taylor & Francis
In this study the activity of Isavuconazole, Voriconazole, Amphotericin B, and Caspofungin
against 224 clinical isolates of Aspergillus spp. originating from seven Italian hospitals, was …

In vitro interaction of isavuconazole and anidulafungin against azole-susceptible and azole-resistant Aspergillus fumigatus isolates

JB Buil, RJM Brüggemann… - Journal of …, 2020 - academic.oup.com
Background The voriconazole and echinocandin combination has been found to be
synergistic in vitro and in vivo against most Aspergillus fumigatus isolates, both with a WT …

In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp

A Raffetin, V Courbin, V Jullien… - Antimicrobial agents and …, 2018 - Am Soc Microbiol
In vitro combinations of isavuconazole with echinocandins were evaluated against 30
Aspergillus strains with a two-dimensional checkerboard microdilution method and an agar …

Colistin and Isavuconazole Interact Synergistically In Vitro against Aspergillus nidulans and Aspergillus niger

P Schwarz, E Djenontin, E Dannaoui - Microorganisms, 2020 - mdpi.com
The in vitro interactions of isavuconazole in combination with colistin were evaluated against
55 clinical Aspergillus species isolates belonging to the five most important species …

Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model

S Seyedmousavi, RJM Brüggemann… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
Azole resistance is an emerging problem in Aspergillus fumigatus which translates into
treatment failure. Alternative treatments with new azoles may improve therapeutic outcome …

Exposure-response relationships for isavuconazole in patients with invasive aspergillosis and other filamentous fungi

AV Desai, LL Kovanda, WW Hope… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Isavuconazole, the active moiety of the water-soluble prodrug isavuconazonium sulfate, is a
triazole antifungal agent for the treatment of invasive fungal infections. The purpose of this …

In Vitro Susceptibility of Aspergillus fumigatus to Isavuconazole: Correlation with Itraconazole, Voriconazole, and Posaconazole

L Gregson, J Goodwin, A Johnson… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in
Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study …

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for Aspergillus spp. for the CLSI M38-A2 broth microdilution method

A Espinel-Ingroff, A Chowdhary… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Epidemiological cutoff values (ECVs) were established for the new triazole isavuconazole
and Aspergillus species wild-type (WT) MIC distributions (organisms in a species-drug …

In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs

MR Shivaprakash, E Geertsen, A Chakrabarti… - Mycoses, 2011 - Wiley Online Library
Recently isavuconazole, an experimental triazole agent, was found to be active against
Aspergillus species. As Aspergillus flavus is the second‐most common Aspergillus species …