There has been a paradigm shift in our understanding of how protein regulation occurs
within mammalian cells in the last 15 years. Our current understanding is that small …

Treatment and cure of HIV-1 infection remain one of the greatest therapeutic challenges
owing to its persistent infection, which often leads to AIDS. Although it has been 28 years …

Cellular microRNAs (miRNAs) are an important class of small, non-coding RNAs that bind to
host mRNAs based on sequence complementarity and regulate protein expression. They …

Importance of the field: HIV-1 is a retrovirus that has infected millions in recent decades. The
level of life cycle complexity and host control exerted by this small virus with only nine …

The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and
effector mechanisms has been highly controversial. Here, we first used deep sequencing of …

HIV-1 has already claimed over 35 million human lives globally. No curative treatments are
currently available, and the only treatment option for over 36 million people currently living …

Despite noteworthy progress made in the management and treatment of HIV/AIDS-related
disease, including the introduction of the now almost ubiquitous HAART, there remains …

Abstract MicroRNAs (miRNAs) are 20–22 nucleotide length noncoding RNA molecules that
represent key regulators of many normal cellular functions. miRNAs undergo two processing …

Over many years, research on HIV/AIDS has advanced with the introduction of HAART.
Despite these advancements, significant gaps remain with respect to aspects in HIV life …

MicroRNAs play critical role in regulating gene expression. MicroRNA profile of particular
cell type bears the signature of cell type specific gene expression. Given that viral pathogens …