The peritoneum represents a confined microenvironment that has an emerging role as a
distinct immunological compartment. In health, this niche is mainly populated by a …

Long term damage to the liver leads to hepatocellular death and development of fibrosis,
which can progress to an advanced stage, known as cirrhosis, associated with severe …

Macrophages are a diverse myeloid cell population involved in innate and adaptive immune
responses, embryonic development, wound repair, and regulation of tissue homeostasis …

Spontaneous and secondary peritoneal infections, mostly of bacterial origin, easily spread to
cause severe sepsis. Cellular and humoral elements of the innate immune system are …

An ascitic microenvironment can condition the immune response of cells from cirrhotic
patients with spontaneous bacterial peritonitis. To characterize this response, we …

Cirrhosis is a multisystemic disease wherein inflammatory responses originating from
advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis …

The peritoneum defines a confined microenvironment, which is stable under normal
conditions, but is exposed to the damaging effect of infections, surgical injuries, and other …

Abstract Changes in intestinal permeability have been determined to influence secondary
inflammatory reactions and clinical manifestations such as spontaneous bacterial peritonitis …

The initial activation of the inflammatory process in the peritoneum is followed by increases
in the intraperitoneal levels of other cytokines as well as the infiltration of leukocytes into the …

Methods Matched peripheral blood and ascites fluid were collected from 46 patients with
decompensated cirrhosis, with or without SBP. Phenotype and function of NK cells and T …