Fetal liver, the major site of hematopoiesis during embryonic development, acquires
additional various metabolic functions near birth. Although liver development has been …

Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros
(AGM) region and migrate to the fetal liver where they massively produce hematopoietic …

Embryonic liver is a transient site for definitive hematopoiesis. Along with maturation of the
bone marrow and spleen, hematopoietic cells relocate from the liver to their final …

Liver development is regulated by soluble factors as well as cell–cell contacts. We
previously reported that oncostatin M (OSM) induced hepatic maturation in a primary culture …

Previously, we described that embryonic day 14.5 (E14. 5) mouse fetal hepatocytes
differentiate to express tyrosine amino transferase (TAT) and glucose-6-phosphatase, which …

Oncostatin M (OSM) is a member of the IL‐6 family of cytokines. Mice deficient in the OSM
receptor (OSMR‐/‐) showed impaired liver regeneration with persistent parenchymal …

Oncostatin M (OSM) is a cytokine which shares a common gene structure and amino acid
sequence similarity with leukemia inhibitory factor (LIF), granulocyte colony-stimulating …

Oncostatin M (OSM) is a multifunctional cytokine that belongs to the interleukin 6 (IL-6)
family. As OSM is expressed in adult as well as embryonic hematopoietic tissues, OSM has …

Oncostatin M (OSM) is a member of a family of cytokines that includes ciliary neurotrophic
factor, interleukin-6, interleukin-11, cardiotrophin-1, and leukemia inhibitory factor (LIF). The …

Hepatocytes have a critical role in metabolism, but their study is limited by the inability to
expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic …