Interstitial fibrosis with tubule atrophy (IF/TA) is the response to virtually any sustained
kidney injury and correlates inversely with kidney function and allograft survival. IF/TA is …

Although kidney transplantation has been an important means for the treatment of patients
with end stage of renal disease, the long-term survival rate of the renal allograft remains a …

To add new molecular and pathogenetic insights into the biological machinery associated to
kidney allograft fibrosis is a major research target in nephrology and organ transplant …

Renal tubulointerstitial fibrosis is the final common pathway of progressive renal diseases. In
allografts, it is assessed with tubular atrophy as interstitial fibrosis/tubular atrophy (IF/TA) …

The prerequisite for successful treatment is an accurate diagnosis, a concept coined
precision medicine. Progression of interstitial fibrosis and tubular atrophy is widely …

Background. Loss of kidney graft function due to interstitial fibrosis (IF) and tubular atrophy
(TA) is the most common cause of kidney allograft loss. Methods. One hundred one allograft …

Tubulointerstitial fibrosis is the terminal consequence of chronic active inflammation of any
cause. The pathophysiology is driven by an imbalance between tubular repair mechanisms …

Every year in the United States, 5000 renal transplant recipients start or restart dialysis
because of the unusual propensity of these allografts to develop interstitial fibrosis and …

Chronic allograft tubular atrophy/interstitial fibrosis (TA/IF) is a major cause of late allograft
loss. A major challenge to the future of kidney transplantation is to dissect the identifiable …

Background. Interstitial fibrosis and tubular atrophy (IF/TA) in renal transplants are the major
morphological correlates of progressive graft deterioration. Early diagnosis of IF/TA is a pre …