Walnut‐derived peptide PW5 ameliorates cognitive impairments and alters gut microbiota in APP/PS1 transgenic mice

M Wang, WK Amakye, L Guo, C Gong… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Decreasing β‐amyloid (Aβ) accumulation is of significance in finding therapeutic
candidates for cognitive impairments in Alzheimer's disease (AD). The aim of this study is to …

Effect of oral and intraperitoneal administration of walnut-derived pentapeptide PW5 on cognitive impairments in APPSWE/PS1ΔE9 mice

M Wang, WK Amakye, C Gong, Z Ren, E Yuan… - Free Radical Biology and …, 2022 - Elsevier
Food-derived bioactive peptides, encrypted in native protein sequence, have attracted
enormous research attention due to its potential in the prevention and/or treatment of a …

Amelioration of walnut-derived novel peptides against d-galactose-induced cognitive impairment by modulating the gut microbiota composition

T Li, L Lin, C Li, J Zheng, B Chen, Y Shen, D Ren - Food & Function, 2023 - pubs.rsc.org
In this work, RLWPF (Arg-Leu-Trp-Pro-Phe) and VLRLF (Val-Leu-Arg-Leu-Phe) were
investigated for the effects against D-galactose (D-gal) induced cognitive impairment by …

Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota–Gut–Brain Axis (MGBA)

Y Qi, X Wang, Y Zhang, Y Leng, X Liu… - Journal of Agricultural …, 2023 - ACS Publications
In this study, we investigated the protective mechanism of walnut-derived peptide LPLLR
(LP-5) against cognitive impairment induced in a dextran sodium sulfate (DSS)-induced …

Insights into the hippocampus proteome and phosphorylation modification alterations in C57BL/6 revealed the memory improvement mechanisms of a walnut-derived …

M Geng, F Zhao, H Lu, L Fang, J Wang, C Liu… - Food Research …, 2022 - Elsevier
This work aimed to explore the underlying mechanisms of memory improvement effects of a
walnut derived peptide WNP-10. The morris water maze test, combined with ultrastructural …

Neuroprotective effect of peptides extracted from walnut (Juglans Sigilata Dode) proteins on Aβ25-35-induced memory impairment in mice

J Zou, P Cai, C Xiong, J Ruan - Journal of Huazhong University of Science …, 2016 - Springer
Alzheimer's disease (AD) is one of the major neurodegenerative disorders of the elderly,
which is characterized by the accumulation and deposition of amyloid-beta (Aβ) peptide in …

Inhibitory Effects of Walnut (Juglans regia) Peptides on Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Induced Cognitive Impairment Mice

S Wang, L Zheng, T Zhao, Q Zhang, Y Liu… - Journal of agricultural …, 2020 - ACS Publications
Increasing level of inflammation and oxidative stress could lead to memory impairment. The
purpose of this study was to determine the neuroprotective effects of walnut peptides against …

Walnut-derived peptides ameliorate d-galactose-induced memory impairments in a mouse model via inhibition of MMP-9-mediated blood–brain barrier disruption

Q Dang, D Wu, Y Li, L Fang, C Liu, X Wang… - Food Research …, 2022 - Elsevier
Disruption of the blood–brain barrier (BBB) has been observed in several neurological
diseases. This study explored the protective effect of the walnut-derived peptide TWLPLPR …

Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through …

QQ Xu, ZR Su, W Yang, M Zhong, YF Xian… - Journal of …, 2023 - Springer
Background Alzheimer's disease (AD) is a chronic neurodegenerative disease
characterized by progressive cognitive dysfunctions and behavioral impairments. Patchouli …

Protective effects of wogonin against Alzheimer's disease by inhibition of amyloidogenic pathway

DS Huang, YC Yu, CH Wu… - … Based Complementary and …, 2017 - Wiley Online Library
One of the pathogenic systems of Alzheimer's disease (AD) is the formation of β‐amyloid
plaques in the brains of patients, and amyloidogenic activity becomes one of the therapeutic …