Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

Organ-on-a-chip (OoC), also known as micro physiological systems or 'tissue chips' have
attracted substantial interest in recent years due to their numerous applications, especially in …

Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …

As a paradigm shifting player of tissue engineering, organs-on-chips (OOCs) are considered
to hold great potential for future “clinical trials on chip” as well as a step forward to design …

Although basic scientific research has generated methodological and technical innovations
rapidly in recent decades, translational science has not kept pace. 1, 2 Among the factors …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

Highlights•A summary of fabrication and research applications of organs-on-chips is
provided.•The current business scenario for organs-on-chips is discussed.•Future changes …

Considerable advances have been made in the development of micro-physiological
systems that seek to faithfully replicate the complexity and functionality of animal and human …