Pericellular proteases have long been associated with cancer invasion and metastasis due
to their ability to degrade extracellular matrix components. Recent studies demonstrate that …

Proteolytic cleavage of extracellular matrix (ECM) is a critical regulator of many physiological
and pathological events. It affects fundamental processes such as cell growth, differentiation …

Pericellular proteases have long been implicated in carcinogenesis. Previous research
focused on these proteins, primarily as extracellular matrix (ECM) protein‐degrading …

Publisher Summary Experimental evidence demonstrates the involvement of proteolytic
activities in a variety of biological processes that involve extracellular matrix (ECM) …

Much progress has been made in understanding how matrix remodeling proteases,
including metalloproteinases, serine proteases, and cysteine cathepsins, functionally …

Proteases are important for multiple processes during malignant progression, including
tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor …

Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

The contribution of extracellular proteolysis to processes of tumor invasion and metastasis
has been recognized for more than 20 years. However, after millions of dollars and untold …

The coordinated control of extracellular matrix degradation on the cell surface involves three
crucial elements: secreted proteases and their inhibitors, surface protease receptors and …

Proteolytic degradation of the extracellular matrix plays a crucial role in both cancer invasion
and non‐neoplastic tissue remodeling processes. In human cancers the components of …